The presynaptic active zone protein RIM1α is critical for normal learning and memory

Craig M Powell, Susanne Schoch, Lisa M Monteggia, Michel Barrot, Maria F. Matos, Nicole Feldmann, Thomas C. Südhof, Eric J. Nestler

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108 Scopus citations

Abstract

The active zone protein RIM1α is required both for maintaining normal probability of neurotransmitter release and for long-term presynaptic potentiation at brain synapses. We now demonstrate that RIM1α -/- mice exhibit normal coordination and anxiety-related behaviors but display severely impaired learning and memory. Mice with a synaptotagmin 1 mutation, which selectively lowers release probability, and mice with Rab3A deletion, which selectively abolishes presynaptic long-term potentiation, do not exhibit this abnormality. Our data suggest that a decrease in release probability or a loss of presynaptic LTP alone is not sufficient to cause major behavioral alterations, but the combination of presynaptic abnormalities in RIM1α-/- mice severely alters learning and memory.

Original languageEnglish (US)
Pages (from-to)143-153
Number of pages11
JournalNeuron
Volume42
Issue number1
DOIs
Publication statusPublished - Apr 8 2004

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Powell, C. M., Schoch, S., Monteggia, L. M., Barrot, M., Matos, M. F., Feldmann, N., ... Nestler, E. J. (2004). The presynaptic active zone protein RIM1α is critical for normal learning and memory. Neuron, 42(1), 143-153. https://doi.org/10.1016/S0896-6273(04)00146-1