TY - JOUR
T1 - The prevalence of occult endometrial cancer in women undergoing hysterectomy for benign indications
AU - Parsons, Lavanya H.Palavalli
AU - Pedersen, Rebecca
AU - Richardson, Debra L.
AU - Kho, Kimberly A.
N1 - Publisher Copyright:
© 2018
PY - 2018/4
Y1 - 2018/4
N2 - Objective: To estimate the frequency of occult endometrial cancer in women undergoing hysterectomy for benign indications. Study design: We performed a retrospective review of all patients undergoing hysterectomies for benign indications at our institution from 2006 to 2014. A departmental database was used to identify all hysterectomies performed, and institutional tumor registry was used to identify cases of endometrial carcinoma. Occult carcinomas were defined as cases with no suspicion preoperatively and histopathologic diagnosis of endometrial cancer postoperatively. Results: A total of 6981 hysterectomies were performed for benign indications. Among these, thirteen patients (0.19%) were found to have occult endometrial cancer, with an overall rate of 1 in 537 patients (95% confidence interval 1:314–1:1008). Twelve patients had stage IA and one had stage IB disease. Median age of women found to have endometrial cancer was 50 years (range 35–72 years). The median BMI was 29.8 kg/m 2 (range 21.3–50.4 kg/m 2 ). The most common indications for hysterectomy were abnormal bleeding (47%), postmenopausal bleeding (15%), adnexal mass (15%), prolapse (15%), and endometrial hyperplasia without atypia (8%). Of the postmenopausal women that had bleeding, all patients underwent evaluation of the endometrium, however 75% of samples did not have adequate amount of endometrium to be evaluated and 25% were found to have hyperplasia. Conclusion: This is one of the largest single institution cohorts to examine occult malignancy. Unexpected endometrial carcinomas were found to occur in 0.19% or 1:537 (95% confidence interval 1:314–1:1008) hysterectomies for benign indications in our population. Précis: Occult endometrial carcinomas are found to occur in 1:537 (0.19%) hysterectomies for benign indications.
AB - Objective: To estimate the frequency of occult endometrial cancer in women undergoing hysterectomy for benign indications. Study design: We performed a retrospective review of all patients undergoing hysterectomies for benign indications at our institution from 2006 to 2014. A departmental database was used to identify all hysterectomies performed, and institutional tumor registry was used to identify cases of endometrial carcinoma. Occult carcinomas were defined as cases with no suspicion preoperatively and histopathologic diagnosis of endometrial cancer postoperatively. Results: A total of 6981 hysterectomies were performed for benign indications. Among these, thirteen patients (0.19%) were found to have occult endometrial cancer, with an overall rate of 1 in 537 patients (95% confidence interval 1:314–1:1008). Twelve patients had stage IA and one had stage IB disease. Median age of women found to have endometrial cancer was 50 years (range 35–72 years). The median BMI was 29.8 kg/m 2 (range 21.3–50.4 kg/m 2 ). The most common indications for hysterectomy were abnormal bleeding (47%), postmenopausal bleeding (15%), adnexal mass (15%), prolapse (15%), and endometrial hyperplasia without atypia (8%). Of the postmenopausal women that had bleeding, all patients underwent evaluation of the endometrium, however 75% of samples did not have adequate amount of endometrium to be evaluated and 25% were found to have hyperplasia. Conclusion: This is one of the largest single institution cohorts to examine occult malignancy. Unexpected endometrial carcinomas were found to occur in 0.19% or 1:537 (95% confidence interval 1:314–1:1008) hysterectomies for benign indications in our population. Précis: Occult endometrial carcinomas are found to occur in 1:537 (0.19%) hysterectomies for benign indications.
KW - Adenocarcinoma
KW - Occult endometrial cancer
KW - Uterine morcellation
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U2 - 10.1016/j.ejogrb.2018.02.017
DO - 10.1016/j.ejogrb.2018.02.017
M3 - Article
C2 - 29518640
AN - SCOPUS:85042878898
SN - 0301-2115
VL - 223
SP - 108
EP - 112
JO - European Journal of Obstetrics and Gynecology and Reproductive Biology
JF - European Journal of Obstetrics and Gynecology and Reproductive Biology
ER -