Abstract
Hand-arm vibration syndrome (HAVS) is a debilitating sequela of neurological and vascular injuries caused by prolonged occupational exposure to hand-transmitted vibration. Our previous study demonstrated that short-term exposure to vibration can induce vasoconstriction and endothelial cell damage in the ventral artery of the rat's tail. The present study investigated whether pretreatment with D-4F, an apolipoprotein A-1 mimetic with known anti-oxidant and vasodilatory properties, prevents vibration-induced vasoconstriction, endothelial cell injury, and protein nitration. Rats were injected intraperitoneally with 3 mg/kg D-4F at 1 h before vibration of the tails for 4 h/day at 60 Hz, 49 m/s2 r. m. s. acceleration for either 1 or 3 days. Vibration-induced endothelial cell damage was examined by light microscopy and nitrotyrosine immunoreactivity (a marker for free radical production). One and 3-day vibration produced vasoconstriction and increased nitrotyrosine. Preemptive treatment with D-4F prevented these negative changes. These findings suggest that D-4F may be useful in the prevention of HAVS.
Original language | English (US) |
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Pages (from-to) | 64-70 |
Number of pages | 7 |
Journal | Hand |
Volume | 6 |
Issue number | 1 |
DOIs | |
State | Published - Mar 2011 |
Keywords
- Apolipoprotein mimetic
- D-4F
- Endothelial cell injury
- HAVS
- Hand arm vibration syndrome
- Occupational Raynaud's
- Vasoconstriction
- Vibration injury
ASJC Scopus subject areas
- Surgery
- Orthopedics and Sports Medicine