The Primary Cilium: Keeper of the Key to Cell Division

Junmin Pan, William Snell

Research output: Contribution to journalShort survey

112 Scopus citations

Abstract

Assembly of the nonmotile primary cilium of vertebrate cells requires one of the centrioles of the centrosome. A cluster of new studies, including one in this issue of Cell by Pugacheva et al. (2007), reveal that ciliary assembly proteins influence cell-cycle progression and that a centrosomal "mitotic kinase" promotes ciliary disassembly. The link between the cell cycle and the primary cilium may reflect a requirement for liberation of the ciliary centriole to allow the centrosome to form the mitotic spindle.

Original languageEnglish (US)
Pages (from-to)1255-1257
Number of pages3
JournalCell
Volume129
Issue number7
DOIs
StatePublished - Jun 29 2007

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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