The Primary Cilium: Keeper of the Key to Cell Division

Junmin Pan; William Snell

doi:10.1016/j.cell.2007.06.018

The Primary Cilium: Keeper of the Key to Cell Division

Junmin Pan, William Snell

Research output: Contribution to journal › Short survey › peer-review

136 Scopus citations

Abstract

Assembly of the nonmotile primary cilium of vertebrate cells requires one of the centrioles of the centrosome. A cluster of new studies, including one in this issue of Cell by Pugacheva et al. (2007), reveal that ciliary assembly proteins influence cell-cycle progression and that a centrosomal "mitotic kinase" promotes ciliary disassembly. The link between the cell cycle and the primary cilium may reflect a requirement for liberation of the ciliary centriole to allow the centrosome to form the mitotic spindle.

Original language	English (US)
Pages (from-to)	1255-1257
Number of pages	3
Journal	Cell
Volume	129
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2007.06.018
State	Published - Jun 29 2007

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2007.06.018

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AB - Assembly of the nonmotile primary cilium of vertebrate cells requires one of the centrioles of the centrosome. A cluster of new studies, including one in this issue of Cell by Pugacheva et al. (2007), reveal that ciliary assembly proteins influence cell-cycle progression and that a centrosomal "mitotic kinase" promotes ciliary disassembly. The link between the cell cycle and the primary cilium may reflect a requirement for liberation of the ciliary centriole to allow the centrosome to form the mitotic spindle.

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The Primary Cilium: Keeper of the Key to Cell Division

Abstract

ASJC Scopus subject areas

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