The prognostic value of CSN6 expression in upper tract urothelial carcinomas

Jhen Hao Jhan, Yi Chen Lee, Wei Ming Li, Lin Li Chang, Wei Chi Hsu, Hui Hui Lin, Peir In Liang, Ya Ling Hsu, Wen Jeng Wu, Hsiang Ying Lee, Ching Chia Li, Hsin Chih Yeh, Hung Lung Ke

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

CSN6 is a subunit of the constitutive photomorphogenesis 9 (COP9) signalosome (CSN). CSN is involved in cellular and developmental processes such as signal transduction, transcriptional activation, cell cycle control, and tumorigenesis. CSN6 is highly expressed in several human cancers, including colorectal cancer, and breast cancer. However, no previous research has elaborated on the relationship between CSN6 expression and survival in patients with upper tract urothelial carcinoma (UTUC). Therefore, the purpose of this study is to evaluate the clinical significance of CSN6 in UTUC. CSN6 expression in 89 patients with UTUC enrolled in this study was examined using immunohistochemistry. The associations between CSN6 expression and clinicopathological variables were analyzed. CSN6 expression was significantly correlated with patients with high pathological stage (P =.006), male gender (P =.025), and high serum creatinine levels (P =.014). In univariate and multivariable analysis, high CSN6 expression was associated with a higher bladder recurrence (P =.005) and poor cancer-specific survival (P =.001) for UTUC. In conclusion, CSN6 expression is a potential biomarker for predicting cancer recurrence and clinical survival in UTUC. Further research is necessary to investigate its role in the progression of UTUC.

Original languageEnglish (US)
Pages (from-to)559-565
Number of pages7
JournalKaohsiung Journal of Medical Sciences
Volume35
Issue number9
DOIs
StatePublished - Sep 1 2019
Externally publishedYes

Keywords

  • CSN6 (COP9 signalosome subunit 6)
  • bladder recurrence
  • cancer-specific survival
  • immunohistochemistry
  • upper tract urothelial carcinoma

ASJC Scopus subject areas

  • Medicine(all)

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