The promise of new drugs for schizophrenia treatment

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Objective: To present aspects of preclinical and clinical pharmacology of new antipsychotic drugs and to emphasize those preclinical drug characteristics which might predict desirable clinical actions. Method: Review of the relevant literature and publicly presented data. Results: Traditional neuroleptics have considerable effectiveness in treating positive symptoms of psychosis but can cause serious motor side effects. Clozapine produces no motor side effects and delivers a unique antipsychotic action. Risperidone also produces low motor side effects, but only at relatively low doses. Olanzapine and sertindole are newly introduced. Both have potent antipsychotic actions, with greatly reduced motor side effects. Both drugs also have possible advantages in negative symptoms. Conclusions: These data support the conclusion that several new antipsychotics are becoming available for general use which are safe and effective in the treatment of psychosis and have several advantages over traditional neuroleptics.

Original languageEnglish (US)
Pages (from-to)265-273
Number of pages9
JournalCanadian Journal of Psychiatry
Volume42
Issue number3
StatePublished - Apr 1997

Fingerprint

Antipsychotic Agents
Schizophrenia
Pharmaceutical Preparations
olanzapine
Psychotic Disorders
Risperidone
Clinical Pharmacology
Clozapine

Keywords

  • clozapine
  • efficacy
  • new antipsychotic
  • olanzapine
  • risperidone
  • schizophrenia
  • sertindol e
  • side effects

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

The promise of new drugs for schizophrenia treatment. / Tamminga, C. A.

In: Canadian Journal of Psychiatry, Vol. 42, No. 3, 04.1997, p. 265-273.

Research output: Contribution to journalArticle

@article{de2d54f58b1040b4b29c0fc93c80f613,
title = "The promise of new drugs for schizophrenia treatment",
abstract = "Objective: To present aspects of preclinical and clinical pharmacology of new antipsychotic drugs and to emphasize those preclinical drug characteristics which might predict desirable clinical actions. Method: Review of the relevant literature and publicly presented data. Results: Traditional neuroleptics have considerable effectiveness in treating positive symptoms of psychosis but can cause serious motor side effects. Clozapine produces no motor side effects and delivers a unique antipsychotic action. Risperidone also produces low motor side effects, but only at relatively low doses. Olanzapine and sertindole are newly introduced. Both have potent antipsychotic actions, with greatly reduced motor side effects. Both drugs also have possible advantages in negative symptoms. Conclusions: These data support the conclusion that several new antipsychotics are becoming available for general use which are safe and effective in the treatment of psychosis and have several advantages over traditional neuroleptics.",
keywords = "clozapine, efficacy, new antipsychotic, olanzapine, risperidone, schizophrenia, sertindol e, side effects",
author = "Tamminga, {C. A.}",
year = "1997",
month = "4",
language = "English (US)",
volume = "42",
pages = "265--273",
journal = "Canadian Journal of Psychiatry",
issn = "0706-7437",
publisher = "Canadian Psychiatric Association",
number = "3",

}

TY - JOUR

T1 - The promise of new drugs for schizophrenia treatment

AU - Tamminga, C. A.

PY - 1997/4

Y1 - 1997/4

N2 - Objective: To present aspects of preclinical and clinical pharmacology of new antipsychotic drugs and to emphasize those preclinical drug characteristics which might predict desirable clinical actions. Method: Review of the relevant literature and publicly presented data. Results: Traditional neuroleptics have considerable effectiveness in treating positive symptoms of psychosis but can cause serious motor side effects. Clozapine produces no motor side effects and delivers a unique antipsychotic action. Risperidone also produces low motor side effects, but only at relatively low doses. Olanzapine and sertindole are newly introduced. Both have potent antipsychotic actions, with greatly reduced motor side effects. Both drugs also have possible advantages in negative symptoms. Conclusions: These data support the conclusion that several new antipsychotics are becoming available for general use which are safe and effective in the treatment of psychosis and have several advantages over traditional neuroleptics.

AB - Objective: To present aspects of preclinical and clinical pharmacology of new antipsychotic drugs and to emphasize those preclinical drug characteristics which might predict desirable clinical actions. Method: Review of the relevant literature and publicly presented data. Results: Traditional neuroleptics have considerable effectiveness in treating positive symptoms of psychosis but can cause serious motor side effects. Clozapine produces no motor side effects and delivers a unique antipsychotic action. Risperidone also produces low motor side effects, but only at relatively low doses. Olanzapine and sertindole are newly introduced. Both have potent antipsychotic actions, with greatly reduced motor side effects. Both drugs also have possible advantages in negative symptoms. Conclusions: These data support the conclusion that several new antipsychotics are becoming available for general use which are safe and effective in the treatment of psychosis and have several advantages over traditional neuroleptics.

KW - clozapine

KW - efficacy

KW - new antipsychotic

KW - olanzapine

KW - risperidone

KW - schizophrenia

KW - sertindol e

KW - side effects

UR - http://www.scopus.com/inward/record.url?scp=0030958385&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030958385&partnerID=8YFLogxK

M3 - Article

C2 - 9114942

AN - SCOPUS:0030958385

VL - 42

SP - 265

EP - 273

JO - Canadian Journal of Psychiatry

JF - Canadian Journal of Psychiatry

SN - 0706-7437

IS - 3

ER -