This chapter focuses on the analysis of the protein products of the murine 17th chromosome. Many of the gene complexes that map between the centromere and TLa play an essential role in cell–cell interactions and the control of immune responsiveness, embryogenesis, and differentiation. All the products of these genes are glycoproteins, most of which are expressed on cell surfaces presumably as receptors and often in association with β-microglobulin. The chapter discusses the present state of biochemical knowledge about these glycoproteins, focusses on their common features and interrelationships, and explores the implications of these qualities for the evolutionary origins of the associated genes. This segment of chromosome 17 acts in some ways as a “super gene” in which the genes and gene complexes coding for a number of functionally interrelated molecules are closely linked, presumably as a result of selective pressures. Significant data concerning the genetics, function, and structure of the I region and its products have been obtained. There is great heterogeneity in the I region. I -region genes and products are involved in a fundamental way with the regulation of the immune response.
ASJC Scopus subject areas
- Immunology and Allergy