TY - JOUR
T1 - The Protein Products of the Murine 17th Chromosome
T2 - Genetics and Structure
AU - Vitetta, E. S.
AU - Capra, J. D.
N1 - Funding Information:
The authors acknowledge the invaluable secretarial assistance of Ms. Bechtel and Ms. Hahn. We extend special appreciation to Drs. Charles E. Wilde 111, James Forman, Richard Cook, and Jonathan W. Uhr for critically reading portions of this manuscript and for many informative discussions. We also thank the many people who have allowed us to reproduce portions of their published work and our many colleagues who have collaborated with us on aspects of our own work presented in this review. The generous grant support of the National Institutes of Health and the National Science Foundation is gratefully acknowledged.
PY - 1978/1/1
Y1 - 1978/1/1
N2 - This chapter focuses on the analysis of the protein products of the murine 17th chromosome. Many of the gene complexes that map between the centromere and TLa play an essential role in cell–cell interactions and the control of immune responsiveness, embryogenesis, and differentiation. All the products of these genes are glycoproteins, most of which are expressed on cell surfaces presumably as receptors and often in association with β-microglobulin. The chapter discusses the present state of biochemical knowledge about these glycoproteins, focusses on their common features and interrelationships, and explores the implications of these qualities for the evolutionary origins of the associated genes. This segment of chromosome 17 acts in some ways as a “super gene” in which the genes and gene complexes coding for a number of functionally interrelated molecules are closely linked, presumably as a result of selective pressures. Significant data concerning the genetics, function, and structure of the I region and its products have been obtained. There is great heterogeneity in the I region. I -region genes and products are involved in a fundamental way with the regulation of the immune response.
AB - This chapter focuses on the analysis of the protein products of the murine 17th chromosome. Many of the gene complexes that map between the centromere and TLa play an essential role in cell–cell interactions and the control of immune responsiveness, embryogenesis, and differentiation. All the products of these genes are glycoproteins, most of which are expressed on cell surfaces presumably as receptors and often in association with β-microglobulin. The chapter discusses the present state of biochemical knowledge about these glycoproteins, focusses on their common features and interrelationships, and explores the implications of these qualities for the evolutionary origins of the associated genes. This segment of chromosome 17 acts in some ways as a “super gene” in which the genes and gene complexes coding for a number of functionally interrelated molecules are closely linked, presumably as a result of selective pressures. Significant data concerning the genetics, function, and structure of the I region and its products have been obtained. There is great heterogeneity in the I region. I -region genes and products are involved in a fundamental way with the regulation of the immune response.
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U2 - 10.1016/S0065-2776(08)60230-8
DO - 10.1016/S0065-2776(08)60230-8
M3 - Article
C2 - 99995
AN - SCOPUS:0017831626
SN - 0065-2776
VL - 26
SP - 147
EP - 193
JO - Advances in Immunology
JF - Advances in Immunology
IS - C
ER -