The RalGEF/Ral Pathway. Evaluating an Intervention Opportunity for Ras Cancers.

Jonathan M. Cooper, Brian O. Bodemann, Michael A. White

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Recognition that Ral guanine nucleotide exchange factors (RalGEFs) are direct Ras effectors and that Ral G-protein activation is a direct consequence of Ras activation has spurred focused efforts to establish the contribution of RalGEF/Ral signaling to oncogenic transformation. Here, we provide a broad-strokes overview of the mechanistic organization of the RalGEF/Ral signaling network, evaluate the evidence for participation of this network in tumorigenic regulatory milieus, consider targeting strategies, and discuss the challenges to and opportunities for clinical development of these targeting strategies.

Original languageEnglish (US)
Pages (from-to)137-156
Number of pages20
JournalEnzymes
Volume34
DOIs
StatePublished - 2013

Keywords

  • Cancer
  • Exo84
  • Exocyst
  • K-Ras
  • MTORC1
  • RalA
  • RalB
  • RALBP1
  • Sec5
  • TBK1
  • ULK1

ASJC Scopus subject areas

  • Biochemistry
  • Biotechnology
  • Biophysics
  • Molecular Biology

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