The rapid and progressive degeneration of the cervical multifi dus in whiplash: An MRI study of fatty infi ltration

James M. Elliott, Mark Courtney, Alfred Rademaker, Daniel Pinto, Michele M. Sterling, Todd B. Parrish

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Study Design. Single-center prospective longitudinal study. Objective. To study the (1) temporal development of muscle fatty infi ltrates (MFI) in the cervical multifi di after whiplash, (2) differences in multifi di MFI between those who recover or report milder pain-related disability and those who report moderate/severe symptoms at 3 months, and (3) predictive value of multifi di MFI outcomes. Summary of Background Data. The temporal development of MFI on conventional magnetic resonance image has been shown to be associated with specifi c aspects of pain and psychological factors. The replication of such findings has yet to be explored longitudinally. Methods. Thirty-six subjects with whiplash injury were enrolled at less than 1 week postinjury and classifi ed at 3 months using percentage scores on the Neck Disability Index as recovered/mild (0%-28%) or severe ( ≥ 30%). A fat/water magnetic resonance imaging measure, patient self-report of pain-related disability, and post-Traumatic stress disorder were collected at less than 1 week, 2 weeks, and 3 months postinjury. The effects of time and group (per Neck Disability Index) and the interaction of time by group on MFI were determined. Receiver operating characteristic curve analysis was used to determine a cut-point for MFiat 2 weeks to predict outcome at 3 months. Results. There was no difference in MFiacross groups at enrolment. MFI values were signifi cantly higher in the severe group than those in the recovered/mild group at 2 weeks and 3 months. The receiver operating characteristic curve analysis indicated that MFI levels of 20.5% or above resulted in a sensitivity of 87.5% and a specifi city of 92.9% for predicting outcome at 3 months. Conclusion. Consistent with previous evidence, muscle degeneration occurs soon after injury but only in those patients with poor functional recovery. This study provides further evidence that (1) multifi di MFI occur in tandem with known predictive risk factors (older age, pain-related disability, and post-Traumatic stress disorder) and (2) routine imaging protocols may need to be reconsidered in the vast majority of patients after whiplash.

Original languageEnglish (US)
Pages (from-to)E694-E700
JournalSpine
Volume40
Issue number12
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Muscles
Temporal Muscle
Pain
Post-Traumatic Stress Disorders
ROC Curve
Neck
Whiplash Injuries
Self Report
Longitudinal Studies
Magnetic Resonance Spectroscopy
Fats
Magnetic Resonance Imaging
Prospective Studies
Psychology
Water
Wounds and Injuries

Keywords

  • Cervical
  • Fat
  • MRI
  • Muscle
  • Pain
  • Post-Traumatic stress disorder
  • Recovery
  • Whiplash

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Clinical Neurology

Cite this

The rapid and progressive degeneration of the cervical multifi dus in whiplash : An MRI study of fatty infi ltration. / Elliott, James M.; Courtney, Mark; Rademaker, Alfred; Pinto, Daniel; Sterling, Michele M.; Parrish, Todd B.

In: Spine, Vol. 40, No. 12, 01.01.2015, p. E694-E700.

Research output: Contribution to journalArticle

Elliott, James M. ; Courtney, Mark ; Rademaker, Alfred ; Pinto, Daniel ; Sterling, Michele M. ; Parrish, Todd B. / The rapid and progressive degeneration of the cervical multifi dus in whiplash : An MRI study of fatty infi ltration. In: Spine. 2015 ; Vol. 40, No. 12. pp. E694-E700.
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N2 - Study Design. Single-center prospective longitudinal study. Objective. To study the (1) temporal development of muscle fatty infi ltrates (MFI) in the cervical multifi di after whiplash, (2) differences in multifi di MFI between those who recover or report milder pain-related disability and those who report moderate/severe symptoms at 3 months, and (3) predictive value of multifi di MFI outcomes. Summary of Background Data. The temporal development of MFI on conventional magnetic resonance image has been shown to be associated with specifi c aspects of pain and psychological factors. The replication of such findings has yet to be explored longitudinally. Methods. Thirty-six subjects with whiplash injury were enrolled at less than 1 week postinjury and classifi ed at 3 months using percentage scores on the Neck Disability Index as recovered/mild (0%-28%) or severe ( ≥ 30%). A fat/water magnetic resonance imaging measure, patient self-report of pain-related disability, and post-Traumatic stress disorder were collected at less than 1 week, 2 weeks, and 3 months postinjury. The effects of time and group (per Neck Disability Index) and the interaction of time by group on MFI were determined. Receiver operating characteristic curve analysis was used to determine a cut-point for MFiat 2 weeks to predict outcome at 3 months. Results. There was no difference in MFiacross groups at enrolment. MFI values were signifi cantly higher in the severe group than those in the recovered/mild group at 2 weeks and 3 months. The receiver operating characteristic curve analysis indicated that MFI levels of 20.5% or above resulted in a sensitivity of 87.5% and a specifi city of 92.9% for predicting outcome at 3 months. Conclusion. Consistent with previous evidence, muscle degeneration occurs soon after injury but only in those patients with poor functional recovery. This study provides further evidence that (1) multifi di MFI occur in tandem with known predictive risk factors (older age, pain-related disability, and post-Traumatic stress disorder) and (2) routine imaging protocols may need to be reconsidered in the vast majority of patients after whiplash.

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