The RB tumor suppressor at the intersection of proliferation and immunity

Relevance to disease immune evasion and immunotherapy

Jack Hutcheson, Agnieszka K. Witkiewicz, Erik S. Knudsen

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The retinoblastoma tumor suppressor (RB) was the first identified tumor suppressor based on germline predisposition to the pediatric eye tumor. Since these early studies, it has become apparent that the functional inactivation of RB is a common event in nearly all human malignancy. A great deal of research has gone into understanding how the loss of RB promotes tumor etiology and progression. Since malignant tumors are characterized by aberrant cell division, much of this research has focused upon the ability of RB to regulate the cell cycle by repression of proliferation-related genes. However, it is progressively understood that RB is an important mediator of multiple functions. One area that is gaining progressive interest is the emerging role for RB in regulating diverse features of immune function. These findings suggest that RB is more than simply a regulator of cellular proliferation;it is at the crossroads of proliferation and the immune response. Here we review the data related to the functional roles of RB on the immune system, relevance to immune evasion, and potential significance to the response to immune-therapy.

Original languageEnglish (US)
Pages (from-to)3812-3819
Number of pages8
JournalCell Cycle
Volume14
Issue number24
DOIs
StatePublished - Jan 1 2015

Fingerprint

Immune Evasion
Immunotherapy
Immunity
Neoplasms
Retinoblastoma
Research
Cell Division
Immune System
Cell Cycle
Cell Proliferation
Pediatrics
Genes

Keywords

  • Anti-viral immunity
  • Differentiation
  • Immune function
  • Immunotherapy
  • RB
  • Transcription
  • Tumor suppressor

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Cite this

The RB tumor suppressor at the intersection of proliferation and immunity : Relevance to disease immune evasion and immunotherapy. / Hutcheson, Jack; Witkiewicz, Agnieszka K.; Knudsen, Erik S.

In: Cell Cycle, Vol. 14, No. 24, 01.01.2015, p. 3812-3819.

Research output: Contribution to journalArticle

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