@article{c13733f109644ea09a2c64f77ab83776,
title = "The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with a cytosolic epoxide hydrolase",
abstract = "Epoxyeicosatrienoic acids, formed during the cytochrome P-450-catalyzed oxidation of arachidonic acid, react with a liver cytosolic epoxide hydrolase to form vicinal diols of eicosatrienoic acid. The role of this cytosolic enzyme, rather than a microsomal bound type, explains previous results illustrating the ability to accumulate epoxides during the in vitro aerobic steady state of oxidative metabolism of arachidonic acid by liver microsomes. The inability of the 5,6-epoxyeicosatrienoic acid to serve as a suitable substrate for this enzyme is discussed in light of recent studies concerning possible unique physiological functions for this metabolite.",
author = "N. Chacos and J. Capdevila and Falck, {J. R.} and S. Manna and C. Martin-Wixtrom and Gill, {S. S.} and Hammock, {B. D.} and Estabrook, {R. W.}",
note = "Funding Information: {\textquoteright} Supported in part by grants from the National Institutes of Health (NIGMS 16488) and (NIEHS 5 ROl ES02710) and the Robert A. Welch Foundation (I-782). B.D.H. was supported by an NIEHS Research Career Development Award (ES 00107). * In analogy to the acronym utilized for the lipoxygenase products (HETE) we would like to introduce the term EET to describe the products of the epoxy-genase pathway of metabolism of arachidonic acid, i.e., the epoxyeicosatrienoic acids. The position of the oxido group is described by the carbon atoms to which oxygen is bonded, e.g., 5,6-epoxyeicosatrienoic acid is abbreviated as 5,6-EET. Correspondingly, the vie-diols resulting from hydration of the EETs are designated by the acronym DHET. Thus the 5,6-dihydroxyei-cosatrienoic acid is abbreviated as 5,6-DHET.",
year = "1983",
month = jun,
doi = "10.1016/0003-9861(83)90628-8",
language = "English (US)",
volume = "223",
pages = "639--648",
journal = "Archives of Biochemistry and Biophysics",
issn = "0003-9861",
publisher = "Academic Press Inc.",
number = "2",
}