Abstract
Epoxyeicosatrienoic acids, formed during the cytochrome P-450-catalyzed oxidation of arachidonic acid, react with a liver cytosolic epoxide hydrolase to form vicinal diols of eicosatrienoic acid. The role of this cytosolic enzyme, rather than a microsomal bound type, explains previous results illustrating the ability to accumulate epoxides during the in vitro aerobic steady state of oxidative metabolism of arachidonic acid by liver microsomes. The inability of the 5,6-epoxyeicosatrienoic acid to serve as a suitable substrate for this enzyme is discussed in light of recent studies concerning possible unique physiological functions for this metabolite.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 639-648 |
| Number of pages | 10 |
| Journal | Archives of Biochemistry and Biophysics |
| Volume | 223 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1983 |
Fingerprint
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with a cytosolic epoxide hydrolase. / Chacos, N.; Capdevila, J.; Falck, J. R.; Manna, S.; Martin-Wixtrom, C.; Gill, S. S.; Hammock, B. D.; Estabrook, R. W.
In: Archives of Biochemistry and Biophysics, Vol. 223, No. 2, 1983, p. 639-648.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with a cytosolic epoxide hydrolase
AU - Chacos, N.
AU - Capdevila, J.
AU - Falck, J. R.
AU - Manna, S.
AU - Martin-Wixtrom, C.
AU - Gill, S. S.
AU - Hammock, B. D.
AU - Estabrook, R. W.
PY - 1983
Y1 - 1983
N2 - Epoxyeicosatrienoic acids, formed during the cytochrome P-450-catalyzed oxidation of arachidonic acid, react with a liver cytosolic epoxide hydrolase to form vicinal diols of eicosatrienoic acid. The role of this cytosolic enzyme, rather than a microsomal bound type, explains previous results illustrating the ability to accumulate epoxides during the in vitro aerobic steady state of oxidative metabolism of arachidonic acid by liver microsomes. The inability of the 5,6-epoxyeicosatrienoic acid to serve as a suitable substrate for this enzyme is discussed in light of recent studies concerning possible unique physiological functions for this metabolite.
AB - Epoxyeicosatrienoic acids, formed during the cytochrome P-450-catalyzed oxidation of arachidonic acid, react with a liver cytosolic epoxide hydrolase to form vicinal diols of eicosatrienoic acid. The role of this cytosolic enzyme, rather than a microsomal bound type, explains previous results illustrating the ability to accumulate epoxides during the in vitro aerobic steady state of oxidative metabolism of arachidonic acid by liver microsomes. The inability of the 5,6-epoxyeicosatrienoic acid to serve as a suitable substrate for this enzyme is discussed in light of recent studies concerning possible unique physiological functions for this metabolite.
UR - http://www.scopus.com/inward/record.url?scp=0020623722&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020623722&partnerID=8YFLogxK
U2 - 10.1016/0003-9861(83)90628-8
DO - 10.1016/0003-9861(83)90628-8
M3 - Article
C2 - 6859878
AN - SCOPUS:0020623722
VL - 223
SP - 639
EP - 648
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
SN - 0003-9861
IS - 2
ER -