The regulation of AβPP expression by RNA-binding proteins

Cara J. Westmark, James S. Malter

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Amyloid β-protein precursor (AβPP) is cleaved by β- and γ-secretases to liberate amyloid beta (Aβ), the predominant protein found in the senile plaques associated with Alzheimer's disease (AD) and Down syndrome (Masters et al., 1985). Intense investigation by the scientific community has centered on understanding the molecular pathways that underlie the production and accumulation of Aβ Therapeutics that reduce the levels of this tenacious, plaque-promoting peptide may reduce the ongoing neural dysfunction and neuronal degeneration that occurs so profoundly in AD. AβPP and Aβ production are highly complex and involve still to be elucidated combinations of transcriptional, post-transcriptional, translational and post-translational events that mediate the production, processing and clearance of these proteins. Research in our laboratory for the past two decades has focused on the role of RNA binding proteins (RBPs) in mediating the post-transcriptional as well as translational regulation of APP messenger RNA (mRNA). This review article summarizes our findings, as well as those from other laboratories, describing the identification of regulatory RBPs, where and under what conditions they interact with APP mRNA and how those interactions control AβPP and Aβ synthesis.

Original languageEnglish (US)
Pages (from-to)450-459
Number of pages10
JournalAgeing Research Reviews
Volume11
Issue number4
DOIs
StatePublished - Sep 2012

Fingerprint

RNA-Binding Proteins
Amyloid beta-Protein Precursor
Alzheimer Disease
Staphylococcal Protein A
Amyloid Precursor Protein Secretases
Messenger RNA
Amyloid Plaques
Down Syndrome
Amyloid
Proteins
Peptides
Processing
Research

Keywords

  • AβPP
  • FMRP
  • HnRNP C
  • Nucleolin
  • Post-transcriptional gene regulation

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Biotechnology
  • Molecular Biology
  • Neurology

Cite this

The regulation of AβPP expression by RNA-binding proteins. / Westmark, Cara J.; Malter, James S.

In: Ageing Research Reviews, Vol. 11, No. 4, 09.2012, p. 450-459.

Research output: Contribution to journalArticle

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