The Regulation of Axonemal Bending

Maureen Wirschell, Daniela Nicastro, Mary E. Porter, Winfield S. Sale

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Citations (Scopus)

Abstract

This chapter primarily focuses on the regulatory mechanisms, signaling molecules, and the discovery and structural organization of axonemal components, revealed in studies of Chlamydomonas, which control axonemal bending. It also reviews the use of cryoelectron microscopy for elucidating details of axonemal structure, with particular emphasis on how structural components of the axoneme may contribute to control of flagellar motility. The mechanisms are complex and are only just beginning to be understood, but include a physically integrated network of axonemal structures and signaling proteins required for regulation of the dynein motors. This chapter describes the dyneins, radial spokes, and central pair apparatus. Based on diverse studies in Chlamydomonas, modulation of axonemal bending involves the central pair apparatus, the radial spokes, and the structures including the DRC and the axonemal kinases and phosphatases. The DRC and signaling proteins are thought to regulate dynein-driven microtubule sliding by coupling the central pair apparatus/radial spoke mechanism to the local control of dynein activity.

Original languageEnglish (US)
Title of host publicationThe Chlamydomonas Sourcebook 3-Vol set
PublisherElsevier Inc.
Pages253-282
Number of pages30
Volume3
ISBN (Print)9780123708731
DOIs
StatePublished - Dec 1 2009

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Dyneins
Chlamydomonas
microtubules
phosphotransferases (kinases)
proteins
Axoneme
Cryoelectron Microscopy
Phosphoric Monoester Hydrolases
Microtubules
Proteins
Phosphotransferases
cryo-electron microscopy

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Wirschell, M., Nicastro, D., Porter, M. E., & Sale, W. S. (2009). The Regulation of Axonemal Bending. In The Chlamydomonas Sourcebook 3-Vol set (Vol. 3, pp. 253-282). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-370873-1.00046-0

The Regulation of Axonemal Bending. / Wirschell, Maureen; Nicastro, Daniela; Porter, Mary E.; Sale, Winfield S.

The Chlamydomonas Sourcebook 3-Vol set. Vol. 3 Elsevier Inc., 2009. p. 253-282.

Research output: Chapter in Book/Report/Conference proceedingChapter

Wirschell, M, Nicastro, D, Porter, ME & Sale, WS 2009, The Regulation of Axonemal Bending. in The Chlamydomonas Sourcebook 3-Vol set. vol. 3, Elsevier Inc., pp. 253-282. https://doi.org/10.1016/B978-0-12-370873-1.00046-0
Wirschell M, Nicastro D, Porter ME, Sale WS. The Regulation of Axonemal Bending. In The Chlamydomonas Sourcebook 3-Vol set. Vol. 3. Elsevier Inc. 2009. p. 253-282 https://doi.org/10.1016/B978-0-12-370873-1.00046-0
Wirschell, Maureen ; Nicastro, Daniela ; Porter, Mary E. ; Sale, Winfield S. / The Regulation of Axonemal Bending. The Chlamydomonas Sourcebook 3-Vol set. Vol. 3 Elsevier Inc., 2009. pp. 253-282
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