Régulation de l'activation des cellules cytotoxiques par l'intermédiaire des lymphokines

Translated title of the contribution: The regulation of the activation of cytotoxic lymphocytes may be mediated by a lymphokine

M. Uotila, H. N. Rode, J. Gordon

Research output: Contribution to journalArticlepeer-review

Abstract

MLC-CML reactivity declines after approximately the 7th day of culture. The experiments described were designed to probe the reason for this decline, envisaged as due to the signals (SD or LD determinants) required for CML activation. Either fresh stimulating cells or a lymphokine--blastogenic factor (BF)--were added daily to mixed cultures from the 5th to the 12th day of incubation. Whereas stimulating cells were without effect, added BF maintained both proliferative and cytotoxic activity of the cells in culture. These observations, together with previous results, were interpreted to suggest that helper cells may regulate the activation of cytotoxic lymphocytes by means of soluble mediators.

Translated title of the contributionThe regulation of the activation of cytotoxic lymphocytes may be mediated by a lymphokine
Original languageFrench
Pages (from-to)65-66
Number of pages2
JournalAnnales d'Immunologie
Volume128
Issue number1-2
StatePublished - Jan 1977

ASJC Scopus subject areas

  • Medicine(all)

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