The relation between inflammation and neuropsychological test performance

Valerie H. Balldin, James R. Hall, Robert C. Barber, Linda Hynan, Ramon Diaz-Arrastia, Sid E. O'Bryant

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background. Considerable research documents an association between pro- and anti-inflammatory markers and Alzheimer's disease (AD), yet the differential relation between these markers and neuropsychological functioning in AD and nondemented controls has received less attention. The current study sought to evaluate the relationship between peripheral markers of inflammation (both pro- and anti-inflammatory) and neuropsychological functioning through the Texas Alzheimer's Research and Care Consortium (TARCC) cohort. Methods. There were 320 participants (Probable AD n = 124, Controls n = 196) in the TARCC Longitudinal Research Cohort available for analysis. Regression analyses were utilized to examine the relation between proinflammatory and anti-inflammatory markers and neuropsychological functioning. Follow-up analyses were conducted separately by case versus control status. Results. Proinflammatory and anti-inflammatory markers were found to be associated with neuropsychological testing. Third tertile proinflammatory markers were negatively associated with measures of attention and language, and anti-inflammatory markers were positively associated with measures of immediate verbal memory and delayed verbal and visual memory. Conclusions. These findings support the link between peripheral inflammatory markers and neuropsychological functioning and suggest the utility of examining profiles of inflammatory markers in the future.

Original languageEnglish (US)
Article number703871
JournalInternational Journal of Alzheimer's Disease
DOIs
StatePublished - 2012

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Neuropsychological Tests
Anti-Inflammatory Agents
Inflammation
Alzheimer Disease
Research
Short-Term Memory
Cohort Studies
Language
Regression Analysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Aging
  • Cellular and Molecular Neuroscience
  • Neurology

Cite this

The relation between inflammation and neuropsychological test performance. / Balldin, Valerie H.; Hall, James R.; Barber, Robert C.; Hynan, Linda; Diaz-Arrastia, Ramon; O'Bryant, Sid E.

In: International Journal of Alzheimer's Disease, 2012.

Research output: Contribution to journalArticle

Balldin, Valerie H. ; Hall, James R. ; Barber, Robert C. ; Hynan, Linda ; Diaz-Arrastia, Ramon ; O'Bryant, Sid E. / The relation between inflammation and neuropsychological test performance. In: International Journal of Alzheimer's Disease. 2012.
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AU - O'Bryant, Sid E.

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