The relationship between aberrant methylation and survival in non-small-cell lung cancers

S. Toyooka, M. Suzuki, R. Maruyama, K. O. Toyooka, K. Tsukuda, Y. Fukuyama, T. Iizasa, M. Aoe, H. Date, T. Fujisawa, N. Shimizu, A. F. Gazdar

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66 Scopus citations

Abstract

The present study examined the relationship between methylation of five genes (p16INK4a, RASSF1A, APC, RARβ and CDH13) and patient survival in 351 cases of surgically resected lung cancers. While there was no relationship between the other genes and survival, p16INK4a methylation was significantly related to unfavourable prognosis in lung adenocarcinomas.

Original languageEnglish (US)
Pages (from-to)771-774
Number of pages4
JournalBritish Journal of Cancer
Volume91
Issue number4
StatePublished - Aug 16 2004

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Keywords

  • Adenocarcinoma of lung
  • Methylation
  • Non-small-cell lung cancer
  • p16

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Toyooka, S., Suzuki, M., Maruyama, R., Toyooka, K. O., Tsukuda, K., Fukuyama, Y., Iizasa, T., Aoe, M., Date, H., Fujisawa, T., Shimizu, N., & Gazdar, A. F. (2004). The relationship between aberrant methylation and survival in non-small-cell lung cancers. British Journal of Cancer, 91(4), 771-774.