The relationship between aberrant methylation and survival in non-small-cell lung cancers

S. Toyooka; M. Suzuki; R. Maruyama; K. O. Toyooka; K. Tsukuda; Y. Fukuyama; T. Iizasa; M. Aoe; H. Date; T. Fujisawa; N. Shimizu; A. F. Gazdar

doi:10.1038/sj.bjc.6602013

The relationship between aberrant methylation and survival in non-small-cell lung cancers

S. Toyooka, M. Suzuki, R. Maruyama, K. O. Toyooka, K. Tsukuda, Y. Fukuyama, T. Iizasa, M. Aoe, H. Date, T. Fujisawa, N. Shimizu, A. F. Gazdar

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

The present study examined the relationship between methylation of five genes (p16^INK4a, RASSF1A, APC, RARβ and CDH13) and patient survival in 351 cases of surgically resected lung cancers. While there was no relationship between the other genes and survival, p16^INK4a methylation was significantly related to unfavourable prognosis in lung adenocarcinomas.

Original language	English (US)
Pages (from-to)	771-774
Number of pages	4
Journal	British journal of cancer
Volume	91
Issue number	4
DOIs	https://doi.org/10.1038/sj.bjc.6602013
State	Published - Aug 16 2004

Keywords

Adenocarcinoma of lung
Methylation
Non-small-cell lung cancer
p16

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/sj.bjc.6602013

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AU - Tsukuda, K.

AU - Fukuyama, Y.

AU - Iizasa, T.

AU - Aoe, M.

AU - Date, H.

AU - Fujisawa, T.

AU - Shimizu, N.

AU - Gazdar, A. F.

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AB - The present study examined the relationship between methylation of five genes (p16INK4a, RASSF1A, APC, RARβ and CDH13) and patient survival in 351 cases of surgically resected lung cancers. While there was no relationship between the other genes and survival, p16INK4a methylation was significantly related to unfavourable prognosis in lung adenocarcinomas.

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The relationship between aberrant methylation and survival in non-small-cell lung cancers

Abstract

Keywords

ASJC Scopus subject areas

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