The relationship between aberrant methylation and survival in non-small-cell lung cancers

S. Toyooka, M. Suzuki, R. Maruyama, K. O. Toyooka, K. Tsukuda, Y. Fukuyama, T. Iizasa, M. Aoe, H. Date, T. Fujisawa, N. Shimizu, A. F. Gazdar

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The present study examined the relationship between methylation of five genes (p16INK4a, RASSF1A, APC, RARβ and CDH13) and patient survival in 351 cases of surgically resected lung cancers. While there was no relationship between the other genes and survival, p16INK4a methylation was significantly related to unfavourable prognosis in lung adenocarcinomas.

Original languageEnglish (US)
Pages (from-to)771-774
Number of pages4
JournalBritish Journal of Cancer
Volume91
Issue number4
StatePublished - Aug 16 2004

Fingerprint

p16 Genes
Non-Small Cell Lung Carcinoma
Methylation
Survival
Lung Neoplasms
Adenocarcinoma of lung

Keywords

  • Adenocarcinoma of lung
  • Methylation
  • Non-small-cell lung cancer
  • p16

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Toyooka, S., Suzuki, M., Maruyama, R., Toyooka, K. O., Tsukuda, K., Fukuyama, Y., ... Gazdar, A. F. (2004). The relationship between aberrant methylation and survival in non-small-cell lung cancers. British Journal of Cancer, 91(4), 771-774.

The relationship between aberrant methylation and survival in non-small-cell lung cancers. / Toyooka, S.; Suzuki, M.; Maruyama, R.; Toyooka, K. O.; Tsukuda, K.; Fukuyama, Y.; Iizasa, T.; Aoe, M.; Date, H.; Fujisawa, T.; Shimizu, N.; Gazdar, A. F.

In: British Journal of Cancer, Vol. 91, No. 4, 16.08.2004, p. 771-774.

Research output: Contribution to journalArticle

Toyooka, S, Suzuki, M, Maruyama, R, Toyooka, KO, Tsukuda, K, Fukuyama, Y, Iizasa, T, Aoe, M, Date, H, Fujisawa, T, Shimizu, N & Gazdar, AF 2004, 'The relationship between aberrant methylation and survival in non-small-cell lung cancers', British Journal of Cancer, vol. 91, no. 4, pp. 771-774.
Toyooka S, Suzuki M, Maruyama R, Toyooka KO, Tsukuda K, Fukuyama Y et al. The relationship between aberrant methylation and survival in non-small-cell lung cancers. British Journal of Cancer. 2004 Aug 16;91(4):771-774.
Toyooka, S. ; Suzuki, M. ; Maruyama, R. ; Toyooka, K. O. ; Tsukuda, K. ; Fukuyama, Y. ; Iizasa, T. ; Aoe, M. ; Date, H. ; Fujisawa, T. ; Shimizu, N. ; Gazdar, A. F. / The relationship between aberrant methylation and survival in non-small-cell lung cancers. In: British Journal of Cancer. 2004 ; Vol. 91, No. 4. pp. 771-774.
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