The relationship between baseline diastolic dysfunction and postimplantation invasive hemodynamics with transcatheter aortic valve replacement

Anthony A. Bavry, Taishi Okuno, Seyed Hossein Aalaei-Andabili, Dharam J Kumbhani, Stefan Stortecky, Masahiko Asami, Jonas Lanz, Stephan Windecker, Thomas Pilgrim

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Abnormal invasive hemodynamics after transcatheter aortic valve replacement (TAVR) is associated with poor survival; however, the mechanism is unknown. Hypothesis: Diastolic dysfunction will modify the association between invasive hemodynamics postTAVR and mortality. Methods: Patients with echocardiographic assessment of diastolic function and postTAVR invasive hemodynamic assessment were eligible for the present analysis. Diastology was classified as normal or abnormal (Stages 1 to 3). The aorto-ventricular index (AVi) was calculated as the difference between the aortic diastolic and the left ventricular end-diastolic pressure divided by the heart rate. AVi was categorized as abnormal (AVi < 0.5 mmHg/beats per minute) or normal (≥ 0.5 mmHg/beats per minute). Results: From 1339 TAVR patients, 390 were included in the final analysis. The mean follow-up was 3.3 ± 1.7 years. Diastolic dysfunction was present in 70.9% of the abnormal vs 55.1% of the normal AVi group (P <.001). All-cause mortality was 46% in the abnormal vs 31% in the normal AVi group (P <.001). Adjusted hazard ratio (HR) for AVi < 0.5 mmHg/beats per minute vs AVi ≥0.5 mmHg/beats per minute for intermediate-term mortality was (HR = 1.5, 95% confidence interval [CI] 1.1 to 2.1, P =.017). This association was the same among those with normal diastolic function and those with diastolic dysfunction (P for interaction =.35). Conclusion: Diastolic dysfunction is prevalent among TAVR patients. Low AVi is an independent predictor for poor intermediate-term survival, irrespective of co-morbid diastolic dysfunction.

Original languageEnglish (US)
Pages (from-to)1428-1434
Number of pages7
JournalClinical Cardiology
Volume43
Issue number12
DOIs
StatePublished - Dec 2020

Keywords

  • aortic stenosis
  • aorto-ventricular index
  • diastolic dysfunction
  • filling pressures
  • invasive hemodynamics
  • prognosis
  • transcatheter aortic valve replacement

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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