TY - JOUR
T1 - The relationship between serum prolactin level and sexual functioning among male outpatients with schizophrenia or schizoaffective disorder
T2 - A randomized double-blind trial of risperidone vs. quetiapine
AU - Nakonezny, Paul A.
AU - Byerly, Matthew J.
AU - Rush, A. John
N1 - Funding Information:
This study was supported by NIMH K-Award grant #5K23 MH064930, the Stanley Medical Research Institute, the Betty Jo Hay Distinguished Chair in Mental Health, Mental Health Connections, a partnership between Dallas County Mental Health and Mental Retardation (MHMR) and the Department of Psychiatry of the University of Texas Southwestern Medical Center, and AstraZeneca LP.
PY - 2007/5
Y1 - 2007/5
N2 - Examine the relationship between serum prolactin level and sexual functioning among male outpatients with schizophrenia or schizoaffective disorder who were treated with risperidone or quetiapine. Male outpatients (N = 22, age ≥ 18 years) with schizophrenia or schizoaffective disorder who had experienced risperidone-associated sexual dysfunction prior to the study were randomized to 6 weeks of double-blind risperidone continuation (mean dose = 4.3 mg/day, SD = 1.2) or quetiapine switch (mean dose = 300 mg/day, SD = 66.7) treatment. Serum prolactin levels at baseline and at the end of week 6 (final visit) were obtained. The five-item Arizona Sexual Experience Scale (ASEX) assessed sexual functioning at baseline and at week 6. A mixed linear model analysis of covariance, with baseline ASEX and Positive and Negative Syndrome Scale (PANSS) scores as covariates, was used to examine the relationship between serum prolactin level (at week 6) and sexual functioning (at week 6). The raw (unadjusted) Spearman rank-order correlations (rs) were also used to assess the linear association between serum prolactin level and sexual functioning. For the risperidone treated group (n = 12), there was a significant positive relationship between serum prolactin level and ASEX total score (rs = 0.689, β = 0.17, p =.04) and three of the five ASEX subitems (ASEX subitem 1, strength of sex drive, β = 0.03, p =.04; ASEX subitem 2, sexual arousal, β = 0.04, p =.04; and ASEX subitem 3, penile erection, β = 0.04, p =.02). There was no significant relationship, for the quetiapine group (n = 10), between serum prolactin level and ASEX total score (p =.55) and any of the ASEX subitems (p's >.20). In this 6-week randomized double-blind trial, higher serum prolactin level was related to greater impairment of sexual functioning in male outpatients who were treated with risperidone, but not with quetiapine.
AB - Examine the relationship between serum prolactin level and sexual functioning among male outpatients with schizophrenia or schizoaffective disorder who were treated with risperidone or quetiapine. Male outpatients (N = 22, age ≥ 18 years) with schizophrenia or schizoaffective disorder who had experienced risperidone-associated sexual dysfunction prior to the study were randomized to 6 weeks of double-blind risperidone continuation (mean dose = 4.3 mg/day, SD = 1.2) or quetiapine switch (mean dose = 300 mg/day, SD = 66.7) treatment. Serum prolactin levels at baseline and at the end of week 6 (final visit) were obtained. The five-item Arizona Sexual Experience Scale (ASEX) assessed sexual functioning at baseline and at week 6. A mixed linear model analysis of covariance, with baseline ASEX and Positive and Negative Syndrome Scale (PANSS) scores as covariates, was used to examine the relationship between serum prolactin level (at week 6) and sexual functioning (at week 6). The raw (unadjusted) Spearman rank-order correlations (rs) were also used to assess the linear association between serum prolactin level and sexual functioning. For the risperidone treated group (n = 12), there was a significant positive relationship between serum prolactin level and ASEX total score (rs = 0.689, β = 0.17, p =.04) and three of the five ASEX subitems (ASEX subitem 1, strength of sex drive, β = 0.03, p =.04; ASEX subitem 2, sexual arousal, β = 0.04, p =.04; and ASEX subitem 3, penile erection, β = 0.04, p =.02). There was no significant relationship, for the quetiapine group (n = 10), between serum prolactin level and ASEX total score (p =.55) and any of the ASEX subitems (p's >.20). In this 6-week randomized double-blind trial, higher serum prolactin level was related to greater impairment of sexual functioning in male outpatients who were treated with risperidone, but not with quetiapine.
UR - http://www.scopus.com/inward/record.url?scp=34047221707&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34047221707&partnerID=8YFLogxK
U2 - 10.1080/00926230701267829
DO - 10.1080/00926230701267829
M3 - Article
C2 - 17454518
AN - SCOPUS:34047221707
SN - 0092-623X
VL - 33
SP - 203
EP - 216
JO - Journal of Sex and Marital Therapy
JF - Journal of Sex and Marital Therapy
IS - 3
ER -