The relationship of cardiovascular risk factors to alzheimer disease in choctaw indians

Myron F. Weiner, Linda S. Hynan, Heidi Rossetti, Kyle B. Womack, Roger N. Rosenberg, Yun Hua Gong, Bao Xi Qu

Research output: Contribution to journalArticle

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Abstract

Objectives: To test the hypothesis that cardiovascular risk factors (CRFs) influence predisposition to and the clinical course of Alzheimer disease (AD), the authors compared Choctaw Indians, a group with known high CRF with white persons with AD. In addition to CRF history, the authors investigated the frequency of apolipoprotein E4 (apoE4) genotype andplasma homocysteine (HC) levels. Method: The authors compared 39 Choctaw Indians with AD and 39 Choctaw Indians without AD to 39 white persons with AD with all groups similar in age. CRF history included diabetes, hypertension, high cholesterol or hypolipidemic agent use, or myocardial infarction. The authors also compared plasma HC concentration and apoE4 allele frequency. Results: Choctaw persons with AD differed significantly from white persons with AD in history of hypertension, diabetes, and in HC values but not from Indians without AD. There was a significantly lower apoE4 allele frequency in Choctaw Indian AD than white persons with AD, and both AD groups had an affected first degree relative significantly more often than Indian controls. There was no relationship between the number of CRF and age at onset among Indians or whites, whereas HC concentration was associated with significantly earlier age of onset for Choctaw Indians but not for whites. Conclusions: This small study suggests that in Choctaw Indians modifiable risk factors may play more of a role in disease pathogenesis than in whites and that nonmodifiable risk factors such as apoE4 may play less of a role.

Original languageEnglish (US)
Pages (from-to)423-429
Number of pages7
JournalAmerican Journal of Geriatric Psychiatry
Volume19
Issue number5
DOIs
StatePublished - May 2011

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Alzheimer Disease
Apolipoprotein E4
Homocysteine
Age of Onset
Gene Frequency
History
Hypertension
Hypolipidemic Agents
Myocardial Infarction
Cholesterol
Genotype

Keywords

  • Alzheimer disease
  • American Indian
  • apolipoprotein E
  • cardiovascular risk
  • homocysteine

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology

Cite this

The relationship of cardiovascular risk factors to alzheimer disease in choctaw indians. / Weiner, Myron F.; Hynan, Linda S.; Rossetti, Heidi; Womack, Kyle B.; Rosenberg, Roger N.; Gong, Yun Hua; Qu, Bao Xi.

In: American Journal of Geriatric Psychiatry, Vol. 19, No. 5, 05.2011, p. 423-429.

Research output: Contribution to journalArticle

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