The relationship of eosinophilia with outcomes of Hirschsprung disease in children

Richard Sola, Ashwini S. Poola, Rmaah Memon, Vivekanand Singh, Richard J. Hendrickson, Shawn D. St. Peter, Jason D. Fraser

Research output: Contribution to journalArticle

Abstract

Purpose: It has been postulated that children with Hirschsprung disease (HD) and mucosal eosinophilia have been thought to have poorer outcome, but supporting evidence is lacking. The objective of our study was to review the outcomes of children with HD and mucosal eosinophilia. Methods: A single center, retrospective review was conducted on all patients diagnosed with HD between 1999 and 2016. Pathology specimens were evaluated for mucosal eosinophilia. Demographics, complications, and outcomes were analyzed. Results: A total of 100 patients were diagnosed with HD and 27 had mucosal eosinophilia. Median age at the time of surgery was 12 days (8, 30) and 82 were males. Comparing patients with HD with and without mucosal eosinophilia, there was no statistically significant difference in time to bowel function (2 days vs. 2 days; p = 0.85), time to start feeds (3 days vs. 3 days; p = 0.78) and time to goal feeds (5 days vs. 5 days; p = 0.47). There was no statistically significant difference in feeding issues (13% vs. 9%; p = 1.0) and stooling issues (60% vs. 50%; p = 0.38). There was no statistically significant difference in postoperative complications and readmissions rates (63% vs. 56%; p = 0.53). Conclusion: Hirschsprung-associated mucosal eosinophilia may not increase postoperative complications, and may not change feeding and bowel management. Further prospective studies are in process to evaluate long term follow-up outcomes for this patient population.

Original languageEnglish (US)
Pages (from-to)425-429
Number of pages5
JournalPediatric Surgery International
Volume35
Issue number4
DOIs
Publication statusPublished - Apr 8 2019
Externally publishedYes

    Fingerprint

Keywords

  • Children
  • Eosinophilia
  • Hirschsprung disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

Sola, R., Poola, A. S., Memon, R., Singh, V., Hendrickson, R. J., St. Peter, S. D., & Fraser, J. D. (2019). The relationship of eosinophilia with outcomes of Hirschsprung disease in children. Pediatric Surgery International, 35(4), 425-429. https://doi.org/10.1007/s00383-018-04430-9