The retinoblastoma protein: More than meets the eyes

Stephen X. Skapek, Yue Wei Qian, Eva Y H P Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Over the past 10 years, tumor suppressor genes involved in many human malignancies have been isolated. The retinoblastoma gene was the first such tumor suppressor gene to be cloned. Analysis of the retinoblastoma gene and the retinoblastoma gene product (pRb) has increased our understanding of its diverse functions which include the regulation of cell cycle progression, transcription factor activity, cellular differentiation, and embryonic development. Analysis of proteins which interact with pRb has provided insight into the molecular basis for how pRb regulates these diverse processes. Functional deletion of pRb by homologous recombination proved that pRb indeed has an essential role for normal mouse development. Further study of cells and cell lines derived from these pRb-deficient mouse embryos has provided clues to the molecular basis for how pRb functions to suppress tumor formation in specific tissues. Our present hypothesis is that although pRb has universal effects on the regulation of the cell cycle, it has tissue-restricted effects on the regulation of differentiation, development and tumor-predisposition. This review will address recent developments in the understanding of these functions of pRb.

Original languageEnglish (US)
Pages (from-to)591-626
Number of pages36
JournalProgress in Retinal and Eye Research
Volume16
Issue number4
DOIs
StatePublished - Oct 1997

Fingerprint

Retinoblastoma Genes
Retinoblastoma Protein
Tumor Suppressor Genes
Cell Cycle
Neoplasms
Homologous Recombination
Embryonic Development
Transcription Factors
Embryonic Structures
Cell Line
Proteins

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

The retinoblastoma protein : More than meets the eyes. / Skapek, Stephen X.; Qian, Yue Wei; Lee, Eva Y H P.

In: Progress in Retinal and Eye Research, Vol. 16, No. 4, 10.1997, p. 591-626.

Research output: Contribution to journalArticle

Skapek, Stephen X. ; Qian, Yue Wei ; Lee, Eva Y H P. / The retinoblastoma protein : More than meets the eyes. In: Progress in Retinal and Eye Research. 1997 ; Vol. 16, No. 4. pp. 591-626.
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