Abstract
Over the past 10 years, tumor suppressor genes involved in many human malignancies have been isolated. The retinoblastoma gene was the first such tumor suppressor gene to be cloned. Analysis of the retinoblastoma gene and the retinoblastoma gene product (pRb) has increased our understanding of its diverse functions which include the regulation of cell cycle progression, transcription factor activity, cellular differentiation, and embryonic development. Analysis of proteins which interact with pRb has provided insight into the molecular basis for how pRb regulates these diverse processes. Functional deletion of pRb by homologous recombination proved that pRb indeed has an essential role for normal mouse development. Further study of cells and cell lines derived from these pRb-deficient mouse embryos has provided clues to the molecular basis for how pRb functions to suppress tumor formation in specific tissues. Our present hypothesis is that although pRb has universal effects on the regulation of the cell cycle, it has tissue-restricted effects on the regulation of differentiation, development and tumor-predisposition. This review will address recent developments in the understanding of these functions of pRb.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 591-626 |
| Number of pages | 36 |
| Journal | Progress in Retinal and Eye Research |
| Volume | 16 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 1997 |
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ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
Cite this
The retinoblastoma protein : More than meets the eyes. / Skapek, Stephen X.; Qian, Yue Wei; Lee, Eva Y H P.
In: Progress in Retinal and Eye Research, Vol. 16, No. 4, 10.1997, p. 591-626.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The retinoblastoma protein
T2 - More than meets the eyes
AU - Skapek, Stephen X.
AU - Qian, Yue Wei
AU - Lee, Eva Y H P
PY - 1997/10
Y1 - 1997/10
N2 - Over the past 10 years, tumor suppressor genes involved in many human malignancies have been isolated. The retinoblastoma gene was the first such tumor suppressor gene to be cloned. Analysis of the retinoblastoma gene and the retinoblastoma gene product (pRb) has increased our understanding of its diverse functions which include the regulation of cell cycle progression, transcription factor activity, cellular differentiation, and embryonic development. Analysis of proteins which interact with pRb has provided insight into the molecular basis for how pRb regulates these diverse processes. Functional deletion of pRb by homologous recombination proved that pRb indeed has an essential role for normal mouse development. Further study of cells and cell lines derived from these pRb-deficient mouse embryos has provided clues to the molecular basis for how pRb functions to suppress tumor formation in specific tissues. Our present hypothesis is that although pRb has universal effects on the regulation of the cell cycle, it has tissue-restricted effects on the regulation of differentiation, development and tumor-predisposition. This review will address recent developments in the understanding of these functions of pRb.
AB - Over the past 10 years, tumor suppressor genes involved in many human malignancies have been isolated. The retinoblastoma gene was the first such tumor suppressor gene to be cloned. Analysis of the retinoblastoma gene and the retinoblastoma gene product (pRb) has increased our understanding of its diverse functions which include the regulation of cell cycle progression, transcription factor activity, cellular differentiation, and embryonic development. Analysis of proteins which interact with pRb has provided insight into the molecular basis for how pRb regulates these diverse processes. Functional deletion of pRb by homologous recombination proved that pRb indeed has an essential role for normal mouse development. Further study of cells and cell lines derived from these pRb-deficient mouse embryos has provided clues to the molecular basis for how pRb functions to suppress tumor formation in specific tissues. Our present hypothesis is that although pRb has universal effects on the regulation of the cell cycle, it has tissue-restricted effects on the regulation of differentiation, development and tumor-predisposition. This review will address recent developments in the understanding of these functions of pRb.
UR - http://www.scopus.com/inward/record.url?scp=0030855368&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030855368&partnerID=8YFLogxK
U2 - 10.1016/S1350-9462(96)00033-X
DO - 10.1016/S1350-9462(96)00033-X
M3 - Article
AN - SCOPUS:0030855368
VL - 16
SP - 591
EP - 626
JO - Progress in Retinal and Eye Research
JF - Progress in Retinal and Eye Research
SN - 1350-9462
IS - 4
ER -