The risk of pulmonary edema and colloid osmotic pressure changes during magnesium sulfate infusion

John D. Yeast, Cathanie Halberstadt, Bruce A. Meyer, Gary R. Cohen, James A. Thorp

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

OBJECTIVES: The purposes of this study were to evaluate the effect of magnesium sulfate therapy on colloid osmotic pressure and to determine whether changes in colloid osmotic pressure increased the risk of pulmonary edema. STUDY DESIGN: During a 1-year time period 294 patients received parenteral magnesium sulfate for the treatment of preterm labor or preeclampsia. Both changes in colloid osmotic pressure and magnesium sulfate values and their relationship to clinical outcome parameters were analyzed. RESULTS: Serum magnesium levels were similar for both patients with preeclampsia and patients with preterm labor. Pulmonary edema developed in only four patients, all of whom had preeclampsia and low colloid osmotic pressure values. CONCLUSIONS: This study demonstrated that parenteral magnesium sulfate therapy does not cause significant changes in colloid osmotic pressure values until nearly 48 hours of continuous therapy.

Original languageEnglish (US)
Pages (from-to)1566-1571
Number of pages6
JournalAmerican journal of obstetrics and gynecology
Volume169
Issue number6
DOIs
StatePublished - Dec 1993

Keywords

  • Parenteral magnesium therapy
  • colloid osmotic pressure
  • pulmonary edema

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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