The RNA polymerase II elongation complex

Teijiro Aso, Joan Weliky Conaway, Ronald C. Conaway

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

The initiation stage of transcription by RNA polymerase II has long been regarded as the primary site for regulation of eukaryotic gene expression. Nevertheless, a growing body of evidence reveals that the RNA polymerase II elongation complex is also a major target for regulation. Biochemical studies are implicating an increasing number of transcription factors in the regulation of elongation, and these transcription factors are being found to function by a diverse collection of mechanisms. Moreover, unexpected features of the structure and catalytic mechanism of RNA polymerase II are forcing a reconsideration of long-held views on the mechanics of some of the most basic aspects of polymerase function. In this review, we will describe recent insights into the structures and functions of RNA polymerase II and the transcription factors that control its activity during the elongation stage of eukaryotic messenger RNA synthesis.

Original languageEnglish (US)
Pages (from-to)1419-1428
Number of pages10
JournalFASEB Journal
Volume9
Issue number14
DOIs
StatePublished - 1995
Externally publishedYes

Keywords

  • gene regulation
  • nucleotide excision repair
  • transcription factor
  • transcriptional arrest

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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