The RNA polymerase II general elongation factors

Daniel Reines, Joan Weliky Conaway, Ronald C. Conaway

Research output: Contribution to journalReview articlepeer-review

125 Scopus citations


Synthesis of eukaryotic messenger RNA by RNA polymerase II is governed by the concerted action of a set of general transcription factors that control the activity of polymerase during both the initiation and elongation stages of transcription. To date, five general elongation factors [P-TEFb, SII, TFIIF, Elongin (SIII) and ELL] have been defined biochemically. Here, we discuss these transcription factors and their roles in controlling the activity of the RNA polymerase II elongation complex.

Original languageEnglish (US)
Pages (from-to)351-355
Number of pages5
JournalTrends in biochemical sciences
Issue number9
StatePublished - Sep 1996
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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