TY - JOUR
T1 - The RNA polymerase II general elongation factors
AU - Reines, Daniel
AU - Conaway, Joan Weliky
AU - Conaway, Ronald C.
N1 - Funding Information:
Work in the authors' laboratories is supported by National Institutes of Health Grants GM46331 (D. R.) and GM41628 (J. W. C. and R. C. C.) and by funds provided to the Oklahoma Medical Research Foundation by the H. A. and Mary K. Chapman Charitable Trust (J. W. C. and R. C. C.).
PY - 1996/9
Y1 - 1996/9
N2 - Synthesis of eukaryotic messenger RNA by RNA polymerase II is governed by the concerted action of a set of general transcription factors that control the activity of polymerase during both the initiation and elongation stages of transcription. To date, five general elongation factors [P-TEFb, SII, TFIIF, Elongin (SIII) and ELL] have been defined biochemically. Here, we discuss these transcription factors and their roles in controlling the activity of the RNA polymerase II elongation complex.
AB - Synthesis of eukaryotic messenger RNA by RNA polymerase II is governed by the concerted action of a set of general transcription factors that control the activity of polymerase during both the initiation and elongation stages of transcription. To date, five general elongation factors [P-TEFb, SII, TFIIF, Elongin (SIII) and ELL] have been defined biochemically. Here, we discuss these transcription factors and their roles in controlling the activity of the RNA polymerase II elongation complex.
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U2 - 10.1016/0968-0004(96)10045-1
DO - 10.1016/0968-0004(96)10045-1
M3 - Review article
C2 - 8870500
AN - SCOPUS:0030249832
SN - 0968-0004
VL - 21
SP - 351
EP - 355
JO - Trends in biochemical sciences
JF - Trends in biochemical sciences
IS - 9
ER -