The role and mechanism of epithelial-to-mesenchymal transition in prostate cancer progression

U. Ging Lo, Cheng Fan Lee, Ming Shyue Lee, Jer Tsong Hsieh

Research output: Contribution to journalReview article

48 Scopus citations

Abstract

In prostate cancer (PCa), similar to many other cancers, distant organ metastasis symbolizes the beginning of the end disease, which eventually leads to cancer death. Many mechanisms have been identified in this process that can be rationalized into targeted therapy. Among them, epithelial-to-mesenchymal transition (EMT) is originally characterized as a critical step for cell trans-differentiation during embryo development and now recognized in promoting cancer cells invasiveness because of high mobility and migratory abilities of mesenchymal cells once converted from carcinoma cells. Nevertheless, the underlying pathways leading to EMT appear to be very diverse in different cancer types, which certainly represent a challenge for developing effective intervention. In this article, we have carefully reviewed the key factors involved in EMT of PCa with clinical correlation in hope to facilitate the development of new therapeutic strategy that is expected to reduce the disease mortality.

Original languageEnglish (US)
Article number2079
JournalInternational journal of molecular sciences
Volume18
Issue number10
DOIs
StatePublished - Oct 2017

Keywords

  • Epithelial-to-mesenchymal transition
  • Metastasis
  • Prostate cancer progression

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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