The role of acid and bile reflux in oesophagitis and Barrett's metaplasia

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The precise mechanisms whereby gastro-oesophageal reflux disease causes reflux oesophagitis and Barrett's oesophagus are not clear, even though these diseases have been known to be linked for many years. Recent studies indicate a role for the reflux-induced inflammatory response of oesophageal squamous epithelial cells and the immune cells in the pathogenesis of reflux oesophagitis. Although reflux oesophagitis commonly heals with oesophageal squamous cell regeneration, in some individuals the oesophagus heals through the process of metaplasia, a condition termed Barrett's oesophagus. Recent studies indicate that individual differences in the reflux-mediated response of oesophageal squamous epithelial cells in the type of immune response and/or in signalling pathways that regulate cell proliferation or cell phenotype may determine whether the oesophagus heals with the regeneration of squamous cells or through Barrett's metaplasia.

Original languageEnglish (US)
Pages (from-to)348-352
Number of pages5
JournalBiochemical Society Transactions
Volume38
Issue number2
DOIs
StatePublished - Apr 2010

Fingerprint

Bile Reflux
Peptic Esophagitis
Barrett Esophagus
Bile Acids and Salts
Epithelial Cells
Acids
Esophagus
Regeneration
Esophageal Diseases
Cell proliferation
Metaplasia
Gastroesophageal Reflux
Individuality
Cell Proliferation
Phenotype

Keywords

  • Barrett's metaplasia
  • Bile acid
  • Gastro-oesophageal reflux disease (GORD)
  • Oesophagitis

ASJC Scopus subject areas

  • Biochemistry

Cite this

The role of acid and bile reflux in oesophagitis and Barrett's metaplasia. / Souza, Rhonda F.

In: Biochemical Society Transactions, Vol. 38, No. 2, 04.2010, p. 348-352.

Research output: Contribution to journalArticle

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