TY - JOUR
T1 - The Role of Adaptive Immunity in the Efficacy of Targeted Cancer Therapies
AU - Xu, Meng Michelle
AU - Pu, Yang
AU - Zhang, Yuan
AU - Fu, Yang Xin
N1 - Funding Information:
We thank Daryl Harmon and Jian Qiao for helpful editing and discussions. This work was supported in part by the US National Institutes of Health through the National Cancer Institute grant CA141975.
Publisher Copyright:
© 2015 Elsevier Ltd
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Accumulating evidence indicates that the efficacy of tumor-targeted therapies relies on the host immune response, including targeted small-molecule and antibody approaches that were not previously thought to have an immune component. Here, we review the current understanding of how targeted therapies on tumor cells could have a major impact on the immune response, and how this relates to the therapeutic efficacy of these approaches. In this context, we evaluate different strategies that combine targeted therapies with immunotherapy approaches, and discuss past and ongoing clinical trials. We highlight gaps in knowledge, and argue that significant progress for combined therapies will require a better understanding of the complex interactions between immune cells, the tumor, and the tumor microenvironment (TME) in different cancer settings.
AB - Accumulating evidence indicates that the efficacy of tumor-targeted therapies relies on the host immune response, including targeted small-molecule and antibody approaches that were not previously thought to have an immune component. Here, we review the current understanding of how targeted therapies on tumor cells could have a major impact on the immune response, and how this relates to the therapeutic efficacy of these approaches. In this context, we evaluate different strategies that combine targeted therapies with immunotherapy approaches, and discuss past and ongoing clinical trials. We highlight gaps in knowledge, and argue that significant progress for combined therapies will require a better understanding of the complex interactions between immune cells, the tumor, and the tumor microenvironment (TME) in different cancer settings.
UR - http://www.scopus.com/inward/record.url?scp=84983196456&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983196456&partnerID=8YFLogxK
U2 - 10.1016/j.it.2015.12.007
DO - 10.1016/j.it.2015.12.007
M3 - Review article
C2 - 26778079
AN - SCOPUS:84983196456
SN - 1471-4906
VL - 37
SP - 141
EP - 153
JO - Trends in Immunology
JF - Trends in Immunology
IS - 2
ER -