The role of advanced lipid testing in the prediction of cardiovascular disease

Alvin Chandra, Anand Rohatgi

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Advanced lipid testing has been suggested by some experts to identify patientswith substantial residual risk for more aggressive targeting of lifestyle and pharmacologic therapies. It measures the subpopulation of lipoproteins and apolipoproteins, which include lipoprotein (a), apolipoprotein A-I, and apolipoprotein B, and measures of lipoprotein particle composition such as LDL particle (LPL-P) and HDL particle (HDL-P) number and size. Obesity is associated with smaller LDL-P and HDL-P sizes. Moderate weight loss via fasting/calorie restriction is associated with LDL-P size increase, whereas moderate weight loss via endurance exercise is associated with HDL-P size increase. Diets high in carbohydrates are associated with a more atherogenic advanced lipoprotein profile characterized by smaller LDL-P and HDL-P sizes. In summary, lifestyle changes such as weight loss, exercise, and dietary modification correlate with improvement in the profile of advanced lipoproteins. Regrettably, therapies targeting HDL and HDL composition have been disappointing to date.

Original languageEnglish (US)
Article number394
JournalCurrent atherosclerosis reports
Volume16
Issue number3
DOIs
StatePublished - Mar 2014

Keywords

  • Diet
  • Exercise
  • Lipoprotein
  • Particles

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'The role of advanced lipid testing in the prediction of cardiovascular disease'. Together they form a unique fingerprint.

  • Cite this