The effect of antigen was examined in vitro under conditions where precursors (B cells) were limiting compared to accessory cells, e.g., carrier specific, thymus-derived cells (T cells), and adherent cells (A cells). Selective initiation of precursors was found at very low concentrations of antigen, further antigen was found to have an effect on clone size or "burst" size over a wide-range of antigen concentrations. Inhibition of the in vitro primary anti-hapten immune response by polyvalent, non-immunogenic, TNP-HSA seemed to occur by selective prevention of the initiation of precursors to plaque forming cells.
ASJC Scopus subject areas
- Cell Biology