The role of antigen in the immune response: Analysis by limiting dilution methods

J. Kettman, R. W. Dutton

Research output: Contribution to journalArticle

7 Scopus citations


The effect of antigen was examined in vitro under conditions where precursors (B cells) were limiting compared to accessory cells, e.g., carrier specific, thymus-derived cells (T cells), and adherent cells (A cells). Selective initiation of precursors was found at very low concentrations of antigen, further antigen was found to have an effect on clone size or "burst" size over a wide-range of antigen concentrations. Inhibition of the in vitro primary anti-hapten immune response by polyvalent, non-immunogenic, TNP-HSA seemed to occur by selective prevention of the initiation of precursors to plaque forming cells.

Original languageEnglish (US)
Pages (from-to)228-239
Number of pages12
JournalCellular Immunology
Issue number1
StatePublished - 1975


ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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