TY - JOUR
T1 - The role of antigen in the immune response
T2 - Analysis by limiting dilution methods
AU - Kettman, J.
AU - Dutton, R. W.
PY - 1975/5
Y1 - 1975/5
N2 - The effect of antigen was examined in vitro under conditions where precursors (B cells) were limiting compared to accessory cells, e.g., carrier specific, thymus-derived cells (T cells), and adherent cells (A cells). Selective initiation of precursors was found at very low concentrations of antigen, further antigen was found to have an effect on clone size or "burst" size over a wide-range of antigen concentrations. Inhibition of the in vitro primary anti-hapten immune response by polyvalent, non-immunogenic, TNP-HSA seemed to occur by selective prevention of the initiation of precursors to plaque forming cells.
AB - The effect of antigen was examined in vitro under conditions where precursors (B cells) were limiting compared to accessory cells, e.g., carrier specific, thymus-derived cells (T cells), and adherent cells (A cells). Selective initiation of precursors was found at very low concentrations of antigen, further antigen was found to have an effect on clone size or "burst" size over a wide-range of antigen concentrations. Inhibition of the in vitro primary anti-hapten immune response by polyvalent, non-immunogenic, TNP-HSA seemed to occur by selective prevention of the initiation of precursors to plaque forming cells.
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U2 - 10.1016/S0008-8749(75)80022-0
DO - 10.1016/S0008-8749(75)80022-0
M3 - Article
C2 - 1092472
AN - SCOPUS:0016735408
SN - 0008-8749
VL - 17
SP - 228
EP - 239
JO - Cellular Immunology
JF - Cellular Immunology
IS - 1
ER -