The histories of tumor necrosis factor (TNF) and cachectin have recently converged, with the recognition that they are one and the same molecule. Cachectin/TNF appears to be a major factor in the pathology that accompanies invasion by a foreign organism - the host mounts an exagerated response that is itself debilatory. Here, Bruce Beutler and Anthony Cerami review the involvement of cachectin/TNF in wasting and shock, as well as its more beneficial influences.
|Original language||English (US)|
|Number of pages||4|
|Journal||Trends in Immunology|
|State||Published - 1988|
ASJC Scopus subject areas
- Immunology and Allergy