The role of cardiac sympathetic innervation and skin thermoreceptors on cardiac responses during heat stress

Manabu Shibasaki, Yasunori Umemoto, Tokio Kinoshita, Tomoyuki Ito, Ken Kouda, Takeshi Nakamura, Craig G. Crandall, Fumihiro Tajima

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The mechanism(s) for the changes in cardiac function during heat stress remain unknown. This study tested two unique hypotheses. First, sympathetic innervation to the heart is required for increases in cardiac systolic function during heat stress. This was accomplished by comparing responses during heat stress between paraplegics versus tetraplegics, with tetraplegics having reduced/absent cardiac sympathetic innervation. Second, stimulation of skin thermoreceptors contributes to cardiovascular adjustments that occur during heat stress in humans. This was accomplished by comparing responses during leg only heating between paraplegic versus able-bodied individuals. Nine healthy able-bodied, nine paraplegics, and eight tetraplegics participated in this study. Lower body (i.e., nonsensed area for para/ tetraplegics) was heated until esophageal temperature had increased by ~1.0°C. Echocardiographic indexes of diastolic and systolic function were performed before and at the end of heat stress. The heat stress increased cardiac output in all groups, but the magnitude of this increase was attenuated in the tetraplegics relative to the able-bodied (1.3 ± 0.4 vs. 2.3 ± 1.0 l/min; P < 0.05). Diastolic function was maintained in all groups. Indexes of left atrial and ventricular systolic function were enhanced in the able-bodied, but did not change in tetraplegics, while these changes in paraplegics were attenuated relative to the able-bodied. These data suggest that the cardiac sympathetic innervation is required to achieve normal increases in cardiac systolic function during heat stress but not required to maintain diastolic function during this exposure. Second, elevated systolic function during heat stress primarily occurs as a result of increases in internal temperature, although stimulation of skin thermoreceptors may contribute.

Original languageEnglish (US)
Pages (from-to)H1336-H1342
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume308
Issue number11
DOIs
StatePublished - Jun 1 2015

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Thermoreceptors
Heat-Shock Response
Hot Temperature
Skin
Temperature
Ventricular Function
Cardiac Output
Heating
Leg

Keywords

  • Cardiac systolic and diastolic function
  • Hyperthermia
  • Skin thermal receptors

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

The role of cardiac sympathetic innervation and skin thermoreceptors on cardiac responses during heat stress. / Shibasaki, Manabu; Umemoto, Yasunori; Kinoshita, Tokio; Ito, Tomoyuki; Kouda, Ken; Nakamura, Takeshi; Crandall, Craig G.; Tajima, Fumihiro.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 308, No. 11, 01.06.2015, p. H1336-H1342.

Research output: Contribution to journalArticle

Shibasaki, Manabu ; Umemoto, Yasunori ; Kinoshita, Tokio ; Ito, Tomoyuki ; Kouda, Ken ; Nakamura, Takeshi ; Crandall, Craig G. ; Tajima, Fumihiro. / The role of cardiac sympathetic innervation and skin thermoreceptors on cardiac responses during heat stress. In: American Journal of Physiology - Heart and Circulatory Physiology. 2015 ; Vol. 308, No. 11. pp. H1336-H1342.
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