The role of cell surface recognition structures in the initiation of MHC-unrestricted 'promiscuous' killing by T cells

Dwain L Thiele; Peter E. Lipsky

doi:10.1016/0167-5699(89)90271-5

The role of cell surface recognition structures in the initiation of MHC-unrestricted 'promiscuous' killing by T cells

Dwain L Thiele, Peter E. Lipsky

Internal Medicine

Research output: Contribution to journal › Review article › peer-review

72 Scopus citations

Abstract

CD3⁺ T cells mediate relatively promiscuous patterns of major histocompatibility complex (MHC)-unrestricted target cell lysis following activation. Cell-cell contact between target and effector cells is essential in this form of cytotoxicity. Although the T-cell receptor (TCR)-CD3 molecular complex can transmit signals that initiate MHC unrestricted T-cell killing, recognition of targets by the TCR is not essential for this form of cytotoxicity. In this review by Dwain Thiele and Peter Lipsky, a model of the triggering of T cells to effect MHC-unrestricted cytotoxicity is proposed.

Original language	English (US)
Pages (from-to)	375-381
Number of pages	7
Journal	Immunology Today
Volume	10
Issue number	11
DOIs	https://doi.org/10.1016/0167-5699(89)90271-5
State	Published - Nov 1989

ASJC Scopus subject areas

Immunology

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10.1016/0167-5699(89)90271-5

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abstract = "CD3+ T cells mediate relatively promiscuous patterns of major histocompatibility complex (MHC)-unrestricted target cell lysis following activation. Cell-cell contact between target and effector cells is essential in this form of cytotoxicity. Although the T-cell receptor (TCR)-CD3 molecular complex can transmit signals that initiate MHC unrestricted T-cell killing, recognition of targets by the TCR is not essential for this form of cytotoxicity. In this review by Dwain Thiele and Peter Lipsky, a model of the triggering of T cells to effect MHC-unrestricted cytotoxicity is proposed.",

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N2 - CD3+ T cells mediate relatively promiscuous patterns of major histocompatibility complex (MHC)-unrestricted target cell lysis following activation. Cell-cell contact between target and effector cells is essential in this form of cytotoxicity. Although the T-cell receptor (TCR)-CD3 molecular complex can transmit signals that initiate MHC unrestricted T-cell killing, recognition of targets by the TCR is not essential for this form of cytotoxicity. In this review by Dwain Thiele and Peter Lipsky, a model of the triggering of T cells to effect MHC-unrestricted cytotoxicity is proposed.

AB - CD3+ T cells mediate relatively promiscuous patterns of major histocompatibility complex (MHC)-unrestricted target cell lysis following activation. Cell-cell contact between target and effector cells is essential in this form of cytotoxicity. Although the T-cell receptor (TCR)-CD3 molecular complex can transmit signals that initiate MHC unrestricted T-cell killing, recognition of targets by the TCR is not essential for this form of cytotoxicity. In this review by Dwain Thiele and Peter Lipsky, a model of the triggering of T cells to effect MHC-unrestricted cytotoxicity is proposed.

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The role of cell surface recognition structures in the initiation of MHC-unrestricted 'promiscuous' killing by T cells

Abstract

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