The Role of Chromatin during Transcription

Bing Li, Michael Carey, Jerry L. Workman

Research output: Contribution to journalReview article

2340 Scopus citations

Abstract

Chromatin structure imposes significant obstacles on all aspects of transcription that are mediated by RNA polymerase II. The dynamics of chromatin structure are tightly regulated through multiple mechanisms including histone modification, chromatin remodeling, histone variant incorporation, and histone eviction. In this Review, we highlight advances in our understanding of chromatin regulation and discuss how such regulation affects the binding of transcription factors as well as the initiation and elongation steps of transcription.

Original languageEnglish (US)
Pages (from-to)707-719
Number of pages13
JournalCell
Volume128
Issue number4
DOIs
StatePublished - Feb 23 2007

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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