The role of chronic hypoxia in the development of neurocognitive abnormalities in preterm infants with bronchopulmonary dysplasia

Lakshmi Raman, Michael K. Georgieff, Raghavendra Rao

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Bronchopulmonary dysplasia is the most common pulmonary morbidity in preterm infants and is associated with chronic hypoxia. Animal studies have demonstrated structural, neurochemical and functional alterations due to chronic hypoxia in the developing brain. Long-term impairments in visual-motor, gross and fine motor, articulation, reading, mathematics, spatial memory and attention skills are prevalent in survivors of bronchopulmonary dysplasia, and impairments appear to correlate with the severity of hypoxia. However, due to the simultaneous occurrence of multiple neurodevelopmental risk factors, a primary or potentiating role for chronic hypoxia in these impairments has yet to be conclusively established.

Original languageEnglish (US)
Pages (from-to)359-367
Number of pages9
JournalDevelopmental Science
Volume9
Issue number4
DOIs
StatePublished - Jul 2006

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Bronchopulmonary Dysplasia
Premature Infants
Mathematics
Vision Disorders
Survivors
Reading
Morbidity
Lung
Hypoxia
Brain

ASJC Scopus subject areas

  • Psychology(all)
  • Developmental and Educational Psychology

Cite this

The role of chronic hypoxia in the development of neurocognitive abnormalities in preterm infants with bronchopulmonary dysplasia. / Raman, Lakshmi; Georgieff, Michael K.; Rao, Raghavendra.

In: Developmental Science, Vol. 9, No. 4, 07.2006, p. 359-367.

Research output: Contribution to journalArticle

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