The role of contact lens type, oxygen transmission, and care-related solutions in mediating epithelial homeostasis and Pseudomonas binding to corneal cells: An overview

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Despite the widespread acceptance of silicone hydrogel contact lenses, microbial keratitis remains the most significant complication associated with contact lens wear and Pseudomonas aeruginosa is still recognized as the leading causative organism. The purpose of this review is to summarize and update the current knowledge of the effects of lens type, oxygen transmissibility, wearing mode, and contact-lens care solutions on corneal epithelial biology and lens-induced P. aeruginosa binding from human and animal studies. The collective results of this work suggest that there is a net interactive effect on corneal epithelial cells among these risk factors. Significantly, hyper-oxygen- transmissible lenses in any wearing mode with non-preserved care solutions appear to offer the safest potential clinical choice for contact lens wear.

Original languageEnglish (US)
Pages (from-to)394-398
Number of pages5
JournalEye and Contact Lens
Volume33
Issue number6 PART 2 OF SUPPL 2
DOIs
StatePublished - Nov 2007

Fingerprint

Contact Lenses
Pseudomonas
Lenses
Homeostasis
Oxygen
Pseudomonas aeruginosa
Contact Lens Solutions
Keratitis
Hydrogel
Silicones
Epithelial Cells

Keywords

  • Bacterial binding
  • Care solutions
  • Contact lens
  • Contact lens oxygen

ASJC Scopus subject areas

  • Ophthalmology

Cite this

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abstract = "Despite the widespread acceptance of silicone hydrogel contact lenses, microbial keratitis remains the most significant complication associated with contact lens wear and Pseudomonas aeruginosa is still recognized as the leading causative organism. The purpose of this review is to summarize and update the current knowledge of the effects of lens type, oxygen transmissibility, wearing mode, and contact-lens care solutions on corneal epithelial biology and lens-induced P. aeruginosa binding from human and animal studies. The collective results of this work suggest that there is a net interactive effect on corneal epithelial cells among these risk factors. Significantly, hyper-oxygen- transmissible lenses in any wearing mode with non-preserved care solutions appear to offer the safest potential clinical choice for contact lens wear.",
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