The role of core TNF/LIGHT family members in lymph node homeostasis and remodeling

Mingzhao Zhu, Yang Xin Fu

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Lymph nodes (LNs) maintain active homeostasis at steady state. However, in response to changes in the local environment, such as local infection, cancer, vaccination, and autoimmune disease, dramatic remodeling of LN occurs. This remodeling includes changes in size, lymph and blood flow, immune cell trafficking and cellularity, lymphatic and blood vessel growth and activation, as well as microarchitecture. Therefore, inflammatory conditions often lead to enlarged nodes; after local inflammation resolves, LNs actively regress in size and return to steady state. Remodeling of lymphatic vessels (LVs) and blood vessels (BVs) during both the expansion and regression phases are key steps in controlling LN size as well as function. The cells, membrane-associated molecules, and soluble cytokines that are essential for LV and BV homeostasis as well as dynamic changes in the expansion and regression phases have not been well defined. Understanding the underlying cellular and molecular mechanisms behind LN remodeling would help us to better control undesired immune responses (e.g. inflammation and autoimmune diseases) or promote desired responses (e.g. antitumor immunity and vaccination). In this review, we focus on how the closely related tumor necrosis factor (TNF) members: LIGHT (TNFSF14), lymphotoxin-αβ, and TNF-α contribute to the remodeling of LNs at various stages of inflammation.

Original languageEnglish (US)
Pages (from-to)75-84
Number of pages10
JournalImmunological Reviews
Volume244
Issue number1
DOIs
StatePublished - Nov 1 2011

Fingerprint

Homeostasis
Tumor Necrosis Factor-alpha
Lymph Nodes
Light
Lymphatic Vessels
Blood Vessels
Inflammation
Autoimmune Diseases
Vaccination
Lymphotoxin-alpha
Lymph
Immunity
Cell Membrane
Cytokines
Growth
Infection
Neoplasms

Keywords

  • B cells
  • Cell trafficking
  • Dendritic cells
  • Endothelial cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

The role of core TNF/LIGHT family members in lymph node homeostasis and remodeling. / Zhu, Mingzhao; Fu, Yang Xin.

In: Immunological Reviews, Vol. 244, No. 1, 01.11.2011, p. 75-84.

Research output: Contribution to journalReview article

@article{8625e702b0de4d0ab7dcb72de5aecc42,
title = "The role of core TNF/LIGHT family members in lymph node homeostasis and remodeling",
abstract = "Lymph nodes (LNs) maintain active homeostasis at steady state. However, in response to changes in the local environment, such as local infection, cancer, vaccination, and autoimmune disease, dramatic remodeling of LN occurs. This remodeling includes changes in size, lymph and blood flow, immune cell trafficking and cellularity, lymphatic and blood vessel growth and activation, as well as microarchitecture. Therefore, inflammatory conditions often lead to enlarged nodes; after local inflammation resolves, LNs actively regress in size and return to steady state. Remodeling of lymphatic vessels (LVs) and blood vessels (BVs) during both the expansion and regression phases are key steps in controlling LN size as well as function. The cells, membrane-associated molecules, and soluble cytokines that are essential for LV and BV homeostasis as well as dynamic changes in the expansion and regression phases have not been well defined. Understanding the underlying cellular and molecular mechanisms behind LN remodeling would help us to better control undesired immune responses (e.g. inflammation and autoimmune diseases) or promote desired responses (e.g. antitumor immunity and vaccination). In this review, we focus on how the closely related tumor necrosis factor (TNF) members: LIGHT (TNFSF14), lymphotoxin-αβ, and TNF-α contribute to the remodeling of LNs at various stages of inflammation.",
keywords = "B cells, Cell trafficking, Dendritic cells, Endothelial cells",
author = "Mingzhao Zhu and Fu, {Yang Xin}",
year = "2011",
month = "11",
day = "1",
doi = "10.1111/j.1600-065X.2011.01061.x",
language = "English (US)",
volume = "244",
pages = "75--84",
journal = "Immunological Reviews",
issn = "0105-2896",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - The role of core TNF/LIGHT family members in lymph node homeostasis and remodeling

AU - Zhu, Mingzhao

AU - Fu, Yang Xin

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Lymph nodes (LNs) maintain active homeostasis at steady state. However, in response to changes in the local environment, such as local infection, cancer, vaccination, and autoimmune disease, dramatic remodeling of LN occurs. This remodeling includes changes in size, lymph and blood flow, immune cell trafficking and cellularity, lymphatic and blood vessel growth and activation, as well as microarchitecture. Therefore, inflammatory conditions often lead to enlarged nodes; after local inflammation resolves, LNs actively regress in size and return to steady state. Remodeling of lymphatic vessels (LVs) and blood vessels (BVs) during both the expansion and regression phases are key steps in controlling LN size as well as function. The cells, membrane-associated molecules, and soluble cytokines that are essential for LV and BV homeostasis as well as dynamic changes in the expansion and regression phases have not been well defined. Understanding the underlying cellular and molecular mechanisms behind LN remodeling would help us to better control undesired immune responses (e.g. inflammation and autoimmune diseases) or promote desired responses (e.g. antitumor immunity and vaccination). In this review, we focus on how the closely related tumor necrosis factor (TNF) members: LIGHT (TNFSF14), lymphotoxin-αβ, and TNF-α contribute to the remodeling of LNs at various stages of inflammation.

AB - Lymph nodes (LNs) maintain active homeostasis at steady state. However, in response to changes in the local environment, such as local infection, cancer, vaccination, and autoimmune disease, dramatic remodeling of LN occurs. This remodeling includes changes in size, lymph and blood flow, immune cell trafficking and cellularity, lymphatic and blood vessel growth and activation, as well as microarchitecture. Therefore, inflammatory conditions often lead to enlarged nodes; after local inflammation resolves, LNs actively regress in size and return to steady state. Remodeling of lymphatic vessels (LVs) and blood vessels (BVs) during both the expansion and regression phases are key steps in controlling LN size as well as function. The cells, membrane-associated molecules, and soluble cytokines that are essential for LV and BV homeostasis as well as dynamic changes in the expansion and regression phases have not been well defined. Understanding the underlying cellular and molecular mechanisms behind LN remodeling would help us to better control undesired immune responses (e.g. inflammation and autoimmune diseases) or promote desired responses (e.g. antitumor immunity and vaccination). In this review, we focus on how the closely related tumor necrosis factor (TNF) members: LIGHT (TNFSF14), lymphotoxin-αβ, and TNF-α contribute to the remodeling of LNs at various stages of inflammation.

KW - B cells

KW - Cell trafficking

KW - Dendritic cells

KW - Endothelial cells

UR - http://www.scopus.com/inward/record.url?scp=80054875663&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054875663&partnerID=8YFLogxK

U2 - 10.1111/j.1600-065X.2011.01061.x

DO - 10.1111/j.1600-065X.2011.01061.x

M3 - Review article

C2 - 22017432

AN - SCOPUS:80054875663

VL - 244

SP - 75

EP - 84

JO - Immunological Reviews

JF - Immunological Reviews

SN - 0105-2896

IS - 1

ER -