Abstract
Earlier studies have shown that an oral sodium (Na) load may induce hypercalciuria in previously normocalciuric subjects and may also increase intestinal calcium (Ca) absorption. To probe the cause of the increased intestinal Ca absorption, we simultaneously measured parathyroid function, serum 1,25-hydroxyvitamin D [1,25-(OH)2D], and fractional intestinal 47Ca absorption before and after a salt load. Eleven normal subjects and two patients with postsurgical hypoparathyroidism were placed on a 10 meq Na, 400 mg Ca per day diet for 10 days, followed by another 10-day period in which the same diet was supplemented by 240 meq Na daily. Measurements were performed on the final 3 days of each phase. In the normal subjects, urinary Na excretion increased from 7 ± 2 to 226 ± 8 meq/day (mean ± SEM), urinary Ca rose from 110 ± 14 to 167 ± 16 mg/day, serum parathyroid hormone (PTH) increased from 20 ± 1 to 22 ± 1 μleq/ml, serum 1,25-(OH)2D rose from 38 ± 4 to 51 ± 7 pg/ml, and fractional intestinal 47Ca absorption increased from 0.39 ± 0.03 to 0.49 ± 0.03 (P < 0.05 for all changes). Serum Ca corrected for total protein did not change (9.9 ± 0.1 to 9.8 ± 0.1 mg/dl). The patients with hypoparathyroidism who were maintained on vitamin D therapy also showed increases in urinary Na (20 ± 12 to 245 ± 11 meq/day) and urinary Ca (271 ± 48 to 305 ± 43; P < 0.05). However, there were no increases in serum PTH (13 ± 1 to 11 ± 1 μleq/ml), serum 1,25-(OH)2D (44 ± 1 to 40 ± 6 pg/ml), or intestinal Ca absorption (0.41 ± 0.03 to 0.42 ± 0.05). Corrected serum Ca decreased from 9.4 ± 0.2 to 8.6 ± 0.2 mg/dl. We conclude that in normal subjects, Na-induced renal hypercalciuria is accompanied by increased 1,25-(OH)2D synthesis and enhanced intestinal Ca absorption. Since this adaptive mechanism did not occur in two patients with hypoparathyroidism, mediation by PTH is suggested.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 369-373 |
| Number of pages | 5 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 55 |
| Issue number | 2 |
| State | Published - 1982 |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology, Diabetes and Metabolism
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The role of dietary sodium on renal excretion and intestinal absorption of calcium and on vitamin D metabolism. / Breslau, N. A.; McGuire, J. L.; Zerwekh, J. E.; Pak, C. Y C.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 55, No. 2, 1982, p. 369-373.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of dietary sodium on renal excretion and intestinal absorption of calcium and on vitamin D metabolism
AU - Breslau, N. A.
AU - McGuire, J. L.
AU - Zerwekh, J. E.
AU - Pak, C. Y C
PY - 1982
Y1 - 1982
N2 - Earlier studies have shown that an oral sodium (Na) load may induce hypercalciuria in previously normocalciuric subjects and may also increase intestinal calcium (Ca) absorption. To probe the cause of the increased intestinal Ca absorption, we simultaneously measured parathyroid function, serum 1,25-hydroxyvitamin D [1,25-(OH)2D], and fractional intestinal 47Ca absorption before and after a salt load. Eleven normal subjects and two patients with postsurgical hypoparathyroidism were placed on a 10 meq Na, 400 mg Ca per day diet for 10 days, followed by another 10-day period in which the same diet was supplemented by 240 meq Na daily. Measurements were performed on the final 3 days of each phase. In the normal subjects, urinary Na excretion increased from 7 ± 2 to 226 ± 8 meq/day (mean ± SEM), urinary Ca rose from 110 ± 14 to 167 ± 16 mg/day, serum parathyroid hormone (PTH) increased from 20 ± 1 to 22 ± 1 μleq/ml, serum 1,25-(OH)2D rose from 38 ± 4 to 51 ± 7 pg/ml, and fractional intestinal 47Ca absorption increased from 0.39 ± 0.03 to 0.49 ± 0.03 (P < 0.05 for all changes). Serum Ca corrected for total protein did not change (9.9 ± 0.1 to 9.8 ± 0.1 mg/dl). The patients with hypoparathyroidism who were maintained on vitamin D therapy also showed increases in urinary Na (20 ± 12 to 245 ± 11 meq/day) and urinary Ca (271 ± 48 to 305 ± 43; P < 0.05). However, there were no increases in serum PTH (13 ± 1 to 11 ± 1 μleq/ml), serum 1,25-(OH)2D (44 ± 1 to 40 ± 6 pg/ml), or intestinal Ca absorption (0.41 ± 0.03 to 0.42 ± 0.05). Corrected serum Ca decreased from 9.4 ± 0.2 to 8.6 ± 0.2 mg/dl. We conclude that in normal subjects, Na-induced renal hypercalciuria is accompanied by increased 1,25-(OH)2D synthesis and enhanced intestinal Ca absorption. Since this adaptive mechanism did not occur in two patients with hypoparathyroidism, mediation by PTH is suggested.
AB - Earlier studies have shown that an oral sodium (Na) load may induce hypercalciuria in previously normocalciuric subjects and may also increase intestinal calcium (Ca) absorption. To probe the cause of the increased intestinal Ca absorption, we simultaneously measured parathyroid function, serum 1,25-hydroxyvitamin D [1,25-(OH)2D], and fractional intestinal 47Ca absorption before and after a salt load. Eleven normal subjects and two patients with postsurgical hypoparathyroidism were placed on a 10 meq Na, 400 mg Ca per day diet for 10 days, followed by another 10-day period in which the same diet was supplemented by 240 meq Na daily. Measurements were performed on the final 3 days of each phase. In the normal subjects, urinary Na excretion increased from 7 ± 2 to 226 ± 8 meq/day (mean ± SEM), urinary Ca rose from 110 ± 14 to 167 ± 16 mg/day, serum parathyroid hormone (PTH) increased from 20 ± 1 to 22 ± 1 μleq/ml, serum 1,25-(OH)2D rose from 38 ± 4 to 51 ± 7 pg/ml, and fractional intestinal 47Ca absorption increased from 0.39 ± 0.03 to 0.49 ± 0.03 (P < 0.05 for all changes). Serum Ca corrected for total protein did not change (9.9 ± 0.1 to 9.8 ± 0.1 mg/dl). The patients with hypoparathyroidism who were maintained on vitamin D therapy also showed increases in urinary Na (20 ± 12 to 245 ± 11 meq/day) and urinary Ca (271 ± 48 to 305 ± 43; P < 0.05). However, there were no increases in serum PTH (13 ± 1 to 11 ± 1 μleq/ml), serum 1,25-(OH)2D (44 ± 1 to 40 ± 6 pg/ml), or intestinal Ca absorption (0.41 ± 0.03 to 0.42 ± 0.05). Corrected serum Ca decreased from 9.4 ± 0.2 to 8.6 ± 0.2 mg/dl. We conclude that in normal subjects, Na-induced renal hypercalciuria is accompanied by increased 1,25-(OH)2D synthesis and enhanced intestinal Ca absorption. Since this adaptive mechanism did not occur in two patients with hypoparathyroidism, mediation by PTH is suggested.
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M3 - Article
C2 - 6896338
AN - SCOPUS:0020380479
VL - 55
SP - 369
EP - 373
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 2
ER -