The role of epigenetics in the pathophysiology of epilepsy

S. M. Nam, K. O. Cho

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Epilepsy is a group of heterogeneous diseases sharing a common feature, seizures. Acute seizures can induce neuronal death, massive gliosis, inflammation, and aberrant neurogenesis in the brain. At a molecular level, seizure activity has been shown to mediate epigenetic changes, including DNA methylation, histone modifications, and the recruitment of noncoding RNAs or chromatin remodeling ATPases. Understanding complex cellular and molecular mechanisms in epilepsy may provide a solid foundation in the development of novel strategies for treating and/or preventing epilepsy. This chapter gives an overview of the seizure-induced cellular alterations in the adult brain and their dysregulation by diverse epigenetic mechanisms in epilepsy.

Original languageEnglish (US)
Title of host publicationNeuropsychiatric Disorders and Epigenetics
PublisherElsevier Inc.
Pages233-260
Number of pages28
ISBN (Print)9780128002261
DOIs
StatePublished - Nov 29 2016

Fingerprint

Epigenomics
Epilepsy
Brain
Seizures
Untranslated RNA
Histones
Chromatin
Adenosine Triphosphatases
Histone Code
Gliosis
Chromatin Assembly and Disassembly
Neurogenesis
DNA Methylation
Inflammation

Keywords

  • Aberrant neurogenesis
  • Chromatin remodeler
  • DNA methylation
  • Epigenetics
  • Epilepsy
  • Histone modification
  • Inflammation
  • Neuronal death
  • Noncoding RNA
  • Reactive astrocytosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Nam, S. M., & Cho, K. O. (2016). The role of epigenetics in the pathophysiology of epilepsy. In Neuropsychiatric Disorders and Epigenetics (pp. 233-260). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800226-1.00012-5

The role of epigenetics in the pathophysiology of epilepsy. / Nam, S. M.; Cho, K. O.

Neuropsychiatric Disorders and Epigenetics. Elsevier Inc., 2016. p. 233-260.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nam, SM & Cho, KO 2016, The role of epigenetics in the pathophysiology of epilepsy. in Neuropsychiatric Disorders and Epigenetics. Elsevier Inc., pp. 233-260. https://doi.org/10.1016/B978-0-12-800226-1.00012-5
Nam SM, Cho KO. The role of epigenetics in the pathophysiology of epilepsy. In Neuropsychiatric Disorders and Epigenetics. Elsevier Inc. 2016. p. 233-260 https://doi.org/10.1016/B978-0-12-800226-1.00012-5
Nam, S. M. ; Cho, K. O. / The role of epigenetics in the pathophysiology of epilepsy. Neuropsychiatric Disorders and Epigenetics. Elsevier Inc., 2016. pp. 233-260
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