The role of epigenetics in the pathophysiology of epilepsy

S. M. Nam, K. O. Cho

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Epilepsy is a group of heterogeneous diseases sharing a common feature, seizures. Acute seizures can induce neuronal death, massive gliosis, inflammation, and aberrant neurogenesis in the brain. At a molecular level, seizure activity has been shown to mediate epigenetic changes, including DNA methylation, histone modifications, and the recruitment of noncoding RNAs or chromatin remodeling ATPases. Understanding complex cellular and molecular mechanisms in epilepsy may provide a solid foundation in the development of novel strategies for treating and/or preventing epilepsy. This chapter gives an overview of the seizure-induced cellular alterations in the adult brain and their dysregulation by diverse epigenetic mechanisms in epilepsy.

Original languageEnglish (US)
Title of host publicationNeuropsychiatric Disorders and Epigenetics
PublisherElsevier Inc.
Pages233-260
Number of pages28
ISBN (Print)9780128002261
DOIs
StatePublished - Jan 1 2017

Keywords

  • Aberrant neurogenesis
  • Chromatin remodeler
  • DNA methylation
  • Epigenetics
  • Epilepsy
  • Histone modification
  • Inflammation
  • Neuronal death
  • Noncoding RNA
  • Reactive astrocytosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'The role of epigenetics in the pathophysiology of epilepsy'. Together they form a unique fingerprint.

  • Cite this

    Nam, S. M., & Cho, K. O. (2017). The role of epigenetics in the pathophysiology of epilepsy. In Neuropsychiatric Disorders and Epigenetics (pp. 233-260). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800226-1.00012-5