The role of ferroptosis in lung cancer

Sikai Wu, Chengchu Zhu, Daolin Tang, Q. Ping Dou, Jianfei Shen, Xin Chen

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Lung cancer is one of the most common cancers in the world. Although medical treatment has made impressive progress in recent years, it is still one of the leading causes of cancer-related deaths in men and women. Ferroptosis is a type of non-apoptotic cell death modality, usually characterized by iron-dependent lipid peroxidation, rather than caspase-induced protein cleavage. Excessive or lack of ferroptosis is associated with a variety of diseases, including cancer and ischaemia-reperfusion injury. Recent preclinical evidence suggests that targeting ferroptotic pathway is a potential strategy for the treatment of lung cancer. In this review, we summarize the core mechanism and regulatory network of ferroptosis in lung cancer cells, and highlight ferroptosis induction-related tumor therapies. The reviewed information may provide new insights for targeted lung cancer therapy.

Original languageEnglish (US)
Article number82
JournalBiomarker Research
Volume9
Issue number1
DOIs
StatePublished - Dec 2021

Keywords

  • Ferroptosis
  • Lipid peroxidation
  • Lung cancer
  • ROS
  • iron

ASJC Scopus subject areas

  • Molecular Medicine
  • Clinical Biochemistry
  • Biochemistry, medical

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