The role of fine-needle aspiration biopsy in the primary diagnosis of mesenchymal lesions a community hospital-based experience

Anirban Maitra, Raheela Ashfaq, M. Hossein Saboorian, Guy Lindberg, S. Tunc Gokaslan

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

BACKGROUND. The objective of this study was to determine the utility of fine-needle aspiration biopsy (FNAB) in the primary diagnosis of mesenchymal lesions. A total of 162 cases with a diagnosis of benign or malignant mesenchymal lesion (excluding lipoma) on FNAB were retrieved from the cytopathology archives for the years 1990-1997. METHODS. Patients selected for inclusion in this study underwent FNAB as the primary diagnostic modality without a previous tissue diagnosis and had a subsequent surgical procedure for definitive histologic correlation. Seventy-two patients were selected on the basis of the above criteria. RESULTS. Cytologic diagnoses were categorized as benign, malignant, or suspicious for malignancy. Among the 72 cases selected, 42 (58%) benign, 18 (25%) malignant, and 12 (16%) suspicious diagnoses were rendered. Of the patients with benign FNAB diagnoses, 39 of 42 (93%) had a benign lesion on histologic follow-up, and 3 of 42 (7%) had a malignancy. Of the patients with malignant FNAB diagnoses, 17 of 18 (94%) had a malignant lesion and 1 of 17 (6%) proved to be benign. In the subset of suspicious lesions, subsequent histology was benign in 5 of 12 (42%) and malignant in 7 of 12 (58%). CONCLUSIONS. Based on our study, FNAB has excellent accuracy (88%), sensitivity (89%), and specificity (87%) for classifying a mesenchymal tumor as benign or malignant. FNAB can be a rapid and effective tool for the primary categorization of mesenchymal lesions and provide reliable information to the clinician for triage of patients. (C) 2000 American Cancer Society.

Original languageEnglish (US)
Pages (from-to)178-185
Number of pages8
JournalCancer
Volume90
Issue number3
DOIs
StatePublished - Jun 25 2000

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Community Hospital
Fine Needle Biopsy
Neoplasms
Lipoma
Triage
Histology
Sensitivity and Specificity

Keywords

  • Cytology
  • Fine-needle aspiration biopsy
  • Mesenchymal
  • Soft tissue

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The role of fine-needle aspiration biopsy in the primary diagnosis of mesenchymal lesions a community hospital-based experience. / Maitra, Anirban; Ashfaq, Raheela; Saboorian, M. Hossein; Lindberg, Guy; Gokaslan, S. Tunc.

In: Cancer, Vol. 90, No. 3, 25.06.2000, p. 178-185.

Research output: Contribution to journalArticle

Maitra, Anirban ; Ashfaq, Raheela ; Saboorian, M. Hossein ; Lindberg, Guy ; Gokaslan, S. Tunc. / The role of fine-needle aspiration biopsy in the primary diagnosis of mesenchymal lesions a community hospital-based experience. In: Cancer. 2000 ; Vol. 90, No. 3. pp. 178-185.
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abstract = "BACKGROUND. The objective of this study was to determine the utility of fine-needle aspiration biopsy (FNAB) in the primary diagnosis of mesenchymal lesions. A total of 162 cases with a diagnosis of benign or malignant mesenchymal lesion (excluding lipoma) on FNAB were retrieved from the cytopathology archives for the years 1990-1997. METHODS. Patients selected for inclusion in this study underwent FNAB as the primary diagnostic modality without a previous tissue diagnosis and had a subsequent surgical procedure for definitive histologic correlation. Seventy-two patients were selected on the basis of the above criteria. RESULTS. Cytologic diagnoses were categorized as benign, malignant, or suspicious for malignancy. Among the 72 cases selected, 42 (58{\%}) benign, 18 (25{\%}) malignant, and 12 (16{\%}) suspicious diagnoses were rendered. Of the patients with benign FNAB diagnoses, 39 of 42 (93{\%}) had a benign lesion on histologic follow-up, and 3 of 42 (7{\%}) had a malignancy. Of the patients with malignant FNAB diagnoses, 17 of 18 (94{\%}) had a malignant lesion and 1 of 17 (6{\%}) proved to be benign. In the subset of suspicious lesions, subsequent histology was benign in 5 of 12 (42{\%}) and malignant in 7 of 12 (58{\%}). CONCLUSIONS. Based on our study, FNAB has excellent accuracy (88{\%}), sensitivity (89{\%}), and specificity (87{\%}) for classifying a mesenchymal tumor as benign or malignant. FNAB can be a rapid and effective tool for the primary categorization of mesenchymal lesions and provide reliable information to the clinician for triage of patients. (C) 2000 American Cancer Society.",
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N2 - BACKGROUND. The objective of this study was to determine the utility of fine-needle aspiration biopsy (FNAB) in the primary diagnosis of mesenchymal lesions. A total of 162 cases with a diagnosis of benign or malignant mesenchymal lesion (excluding lipoma) on FNAB were retrieved from the cytopathology archives for the years 1990-1997. METHODS. Patients selected for inclusion in this study underwent FNAB as the primary diagnostic modality without a previous tissue diagnosis and had a subsequent surgical procedure for definitive histologic correlation. Seventy-two patients were selected on the basis of the above criteria. RESULTS. Cytologic diagnoses were categorized as benign, malignant, or suspicious for malignancy. Among the 72 cases selected, 42 (58%) benign, 18 (25%) malignant, and 12 (16%) suspicious diagnoses were rendered. Of the patients with benign FNAB diagnoses, 39 of 42 (93%) had a benign lesion on histologic follow-up, and 3 of 42 (7%) had a malignancy. Of the patients with malignant FNAB diagnoses, 17 of 18 (94%) had a malignant lesion and 1 of 17 (6%) proved to be benign. In the subset of suspicious lesions, subsequent histology was benign in 5 of 12 (42%) and malignant in 7 of 12 (58%). CONCLUSIONS. Based on our study, FNAB has excellent accuracy (88%), sensitivity (89%), and specificity (87%) for classifying a mesenchymal tumor as benign or malignant. FNAB can be a rapid and effective tool for the primary categorization of mesenchymal lesions and provide reliable information to the clinician for triage of patients. (C) 2000 American Cancer Society.

AB - BACKGROUND. The objective of this study was to determine the utility of fine-needle aspiration biopsy (FNAB) in the primary diagnosis of mesenchymal lesions. A total of 162 cases with a diagnosis of benign or malignant mesenchymal lesion (excluding lipoma) on FNAB were retrieved from the cytopathology archives for the years 1990-1997. METHODS. Patients selected for inclusion in this study underwent FNAB as the primary diagnostic modality without a previous tissue diagnosis and had a subsequent surgical procedure for definitive histologic correlation. Seventy-two patients were selected on the basis of the above criteria. RESULTS. Cytologic diagnoses were categorized as benign, malignant, or suspicious for malignancy. Among the 72 cases selected, 42 (58%) benign, 18 (25%) malignant, and 12 (16%) suspicious diagnoses were rendered. Of the patients with benign FNAB diagnoses, 39 of 42 (93%) had a benign lesion on histologic follow-up, and 3 of 42 (7%) had a malignancy. Of the patients with malignant FNAB diagnoses, 17 of 18 (94%) had a malignant lesion and 1 of 17 (6%) proved to be benign. In the subset of suspicious lesions, subsequent histology was benign in 5 of 12 (42%) and malignant in 7 of 12 (58%). CONCLUSIONS. Based on our study, FNAB has excellent accuracy (88%), sensitivity (89%), and specificity (87%) for classifying a mesenchymal tumor as benign or malignant. FNAB can be a rapid and effective tool for the primary categorization of mesenchymal lesions and provide reliable information to the clinician for triage of patients. (C) 2000 American Cancer Society.

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