The role of GABAergic modulation of mesopontine cholinergic neurotransmission in rapid eye movement (REM) sleep

Gerald A. Marks, Christopher M. Sinton

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The complexity of the pontine neuronal mechanisms that control and modulate expression of rapid eye movement (REM) sleep has been only recently recognized. In this review of some of these mechanisms, results from studies in the cat and rat are summarized and compared, and the differences between neuronal populations that might be effective, modulatory, or executive for REM sleep control are considered. One of the principal pontine areas that has been found to be important for the induction of REM sleep is located in the nucleus pontis oralis. Another is located in a more dorsocaudal area. The latter, designated the peri-locus coeruleus α in the cat, corresponds most closely with the sublaterodorsal (SLD) nucleus in the rat. In both areas in the cat, cholinergic mechanisms are important for REM sleep induction, whereas in the rat, only the pontis oralis area is cholinergically sensitive. In contrast, the SLD is responsive to glutamatergic processes. The emerging recognition of the importance of GABAergic modulation of these sites in both species is reviewed, and from this work, some preliminary conclusions can be drawn. In the caudal pontis oralis of rat, GABAergic mechanisms can affect the release of acetylcholine, inferring that transmitter release in a terminal region can be decoupled from impulse flow. This is important in light of the concept of changes in the discharge rate of reciprocally interacting populations of neurons being correlated with differences in vigilance state. A second conclusion, based on the work in the SLD, is that network interactions are critical for REM sleep control. The latter can be extended to conclude that activation of neurons that are effective for at least two of the signs of REM sleep may be sufficient to induce the state. Distributed networks would obviate the need for a single locus of executive control for REM sleep. But another possibility derived from the SLD studies is that executive control of REM sleep may actually represent the coordination of effective mechanisms, explaining the difficulty that has been encountered in finding a REM sleep generator.

Original languageEnglish (US)
Title of host publicationGABA and Sleep: Molecular, Functional and Clinical Aspects
PublisherSpringer Basel
Pages253-277
Number of pages25
ISBN (Print)9783034602266, 9783034602259
DOIs
StatePublished - 2010

Fingerprint

REM Sleep
Synaptic Transmission
Cholinergic Agents
Sleep
Cats
Executive Function
Neurons
Internal-External Control
Locus Coeruleus
Population
Acetylcholine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Marks, G. A., & Sinton, C. M. (2010). The role of GABAergic modulation of mesopontine cholinergic neurotransmission in rapid eye movement (REM) sleep. In GABA and Sleep: Molecular, Functional and Clinical Aspects (pp. 253-277). Springer Basel. https://doi.org/10.1007/978-3-0346-0226-6-12

The role of GABAergic modulation of mesopontine cholinergic neurotransmission in rapid eye movement (REM) sleep. / Marks, Gerald A.; Sinton, Christopher M.

GABA and Sleep: Molecular, Functional and Clinical Aspects. Springer Basel, 2010. p. 253-277.

Research output: Chapter in Book/Report/Conference proceedingChapter

Marks, GA & Sinton, CM 2010, The role of GABAergic modulation of mesopontine cholinergic neurotransmission in rapid eye movement (REM) sleep. in GABA and Sleep: Molecular, Functional and Clinical Aspects. Springer Basel, pp. 253-277. https://doi.org/10.1007/978-3-0346-0226-6-12
Marks GA, Sinton CM. The role of GABAergic modulation of mesopontine cholinergic neurotransmission in rapid eye movement (REM) sleep. In GABA and Sleep: Molecular, Functional and Clinical Aspects. Springer Basel. 2010. p. 253-277 https://doi.org/10.1007/978-3-0346-0226-6-12
Marks, Gerald A. ; Sinton, Christopher M. / The role of GABAergic modulation of mesopontine cholinergic neurotransmission in rapid eye movement (REM) sleep. GABA and Sleep: Molecular, Functional and Clinical Aspects. Springer Basel, 2010. pp. 253-277
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