The role of hypoxia and exploitation of the hypoxic environment in hematologic malignancies

Barbara Muz, Pilar De La Puente, Feda Azab, Micah Luderer, Abdel Kareem Azab

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

Tumor hypoxia is a well-described phenomenon during the progression of solid tumors affecting cell signaling pathways and cell metabolism; however, its role in hematologic malignancies has not been given the same attention in the literature. Therefore, this review focuses on the comparative differences between solid and hematologic malignancies with emphasis on the role of hypoxia during tumorigenesis and progression. In addition, contribution of the bone marrow and angiogenic environment are also discussed. Insight is provided into the role of hypoxia in metastatic spread, stemness, and drug resistance in hematologic conditions. Finally, emerging therapeutic strategies such as small-molecule prodrugs and hypoxia-inducible factor (HIF) targeting approaches are outlined to combat hypoxic cells and/or adaptive mechanisms in the treatment of hematologic malignancies.

Original languageEnglish (US)
Pages (from-to)1347-1354
Number of pages8
JournalMolecular Cancer Research
Volume12
Issue number10
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Oncology
  • Cancer Research

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