The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca

Koray Gumus, Harrison D Cavanagh

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Purpose: To review and integrate recent advances in identifying the role of inflammation in the pathogenesis of dry eye conditions and the biological rationale and practical clinical aspects of newer, antiinflammatory theories. Methods: A comprehensive literature survey. Results and conclusion: Keratoconjunctivitis Sicca (KCS) is a multifactorial and complex disorder in which ocular surface inflammations play a central role. Identification of specific CD4-T-Cell pathways and the recent recognition of targeting of alpha-fodrin suggest a case for novel new therapeutic aspects such as anti-CD4 monoclonal antibodies, systemic linoleic and gamma-linolenic acids, and omega-6 essential fatty acids. Replacement of tear volume with nonpreserved wetting agents and standard typical antiinflammatory corticosteroid and/or cyclosporine A continues to be central current conventional therapy for KCS.

Original languageEnglish (US)
Pages (from-to)57-67
Number of pages11
JournalClinical Ophthalmology
Volume3
Issue number1
StatePublished - 2009

Fingerprint

Keratoconjunctivitis Sicca
Wetting Agents
Anti-Inflammatory Agents
Omega-6 Fatty Acids
gamma-Linolenic Acid
Inflammation
Essential Fatty Acids
Tears
Cyclosporine
Adrenal Cortex Hormones
Monoclonal Antibodies
T-Lymphocytes
Therapeutics
Surveys and Questionnaires
fodrin

Keywords

  • Antiinflammatory therapy
  • Dry eye
  • Keratoconjunctivitis sicca

ASJC Scopus subject areas

  • Ophthalmology

Cite this

The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca. / Gumus, Koray; Cavanagh, Harrison D.

In: Clinical Ophthalmology, Vol. 3, No. 1, 2009, p. 57-67.

Research output: Contribution to journalArticle

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