The role of LIGHT in T cell-mediated immunity

Jing Wang, Yang X. Fu

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

This review focuses on the role of homologous to lymphotoxin, exhibits inducible expression, competes with herpesvirus glycoprotein D for HVEM on T cells (LIGHT) in T-cell immunity and T cell-mediated diseases. LIGHT binds to lymphotoxin-β receptor (LTβR), and cooperates with LTβ in lymphoid organogenesis and development of lymphoid structure. Previous findings establish a crucial biological role for LIGHT, a T cell-derived costimulatory ligand, in T-cell activation and expansion via a T-T cell-dependent manner. Transgenic studies demonstrated that the dysregulation of LIGHT activity results in the disturbance of T-cell homeostasis and ultimately the breakdown of peripheral tolerance. Furthermore, the blockade of LIGHT activity ameliorates the severity of T cell-mediated diseases indicating the essential involvement of LIGHT in various pathological conditions. Here, we review the recent studies about LIGHT mainly in the context of autoimmunity and conclude with a discussion of the potential mechanisms by which LIGHT promotes autoimmunity.

Original languageEnglish (US)
Pages (from-to)201-214
Number of pages14
JournalImmunologic Research
Volume30
Issue number2
DOIs
StatePublished - Nov 8 2004

Keywords

  • Autoimmunity
  • Chemokine
  • Costimulation
  • HVEM
  • LIGHT
  • LTβR
  • Lymphoid Structure
  • T cell-mediated diseases
  • T-cell activation

ASJC Scopus subject areas

  • Immunology

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