Abstract
Several lines of evidence indicate that enzymes that modify membrane lipids function in the regulation of constitutive membrane traffic. Recent evidence suggests that specific phosphatidylinositides may regulate the activity of proteins with diverse functions in membrane transport, such as dynamin, the clathrin-associated AP-2 complex, and proteins that stimulate guanine nucleotide exchange on ADP-ribosylation factors (ARFs). ARF proteins activate a phospholipase D that produces phosphatidic acid from phosphatidylcholine, and this may be essential for the formation of certain types of transport vesicles or may tie constitutive vesicular transport to signal transduction pathways.
Original language | English (US) |
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Pages (from-to) | 519-526 |
Number of pages | 8 |
Journal | Current Opinion in Cell Biology |
Volume | 9 |
Issue number | 4 |
DOIs | |
State | Published - Aug 1997 |
ASJC Scopus subject areas
- Cell Biology