The role of microRNA in inflammatory bowel disease

Sushila R. Dalal, John H. Kwon

Research output: Contribution to journalArticle

89 Scopus citations

Abstract

Inflammatory bowel disease (IBD) is the consequence of an abnormal immune response to environmental factors in genetically susceptible hosts. microRNAs (miRNAs) are small, 22-nucleotide, noncoding, single-stranded RNA molecules involved in the post-transcriptional regulation of 30% of protein-coding genes. Differential expression of miRNAs is described in multiple autoimmune-related conditions such as psoriasis, rheumatoid arthritis, lupus, and asthma. Recently, unique miRNA expression profiles have been described in epithelial cells of patients with active ulcerative colitis, Crohn's ileitis, and Crohn's colitis, as well as in the peripheral blood of patients with active ulcerative colitis and Crohn's disease. miRNA expression profiles also change in the progression from normal colonic tissue to dysplastic tissue, with unaffected tissue from IBD patients and inflamed tissue from IBD patients showing intermediate profiles. Understanding the role of miRNAs in IBD may lead to future insights into disease pathogenesis, diagnosis, and treatment.

Original languageEnglish (US)
Pages (from-to)714-722
Number of pages9
JournalGastroenterology and Hepatology
Volume6
Issue number11
StatePublished - Nov 1 2010

Keywords

  • Crohn's disease
  • Gene expression
  • Inflammatory bowel disease
  • MicroRNA
  • Ulcerative colitis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Dalal, S. R., & Kwon, J. H. (2010). The role of microRNA in inflammatory bowel disease. Gastroenterology and Hepatology, 6(11), 714-722.