The role of MicroRNAs in hematopoietic stem cells and leukemia development

Safak Yalcin, Stephen S. Chung, Christopher Y. Park

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Hematopoietic stem cells (HSCs) are multipotent cells capable of self-renewal as well as differentiation into all mature blood cell types to sustain lifelong hematopoiesis. Leukemias are thought to be initiated and maintained by leukemic stem cells (LSCs), which also have the capacity for self-renewal, but they are also characterized by varying levels of impaired differentiation and increased proliferation which give rise to disease phenotypes. LSCs and HSCs share the common ability to self-renew, and they may rely on similar pathways for this unique function. Thus, it is critical to understand the molecular mechanisms shared between these two cell populations, as these are likely to represent key features that drive leukemic transformation of HSCs and/or their downstream progeny. Recently, microRNAs (miRNAs) have been implicated as important regulators of self-renewal and differentiation in the hematopoietic system. Profiling of normal and malignant hematopoietic cells, corroborated with a limited but growing number of functional studies, has demonstrated that miRNAs are critical regulators of HSC function, are dysregulated in leukemias, and likely play an important role in leukemogenesis. Herein, we will review these studies and discuss their contributions toward our understanding of the importance of miRNAs in normal and malignant stem cell function in the hematopoietic system.

Original languageEnglish (US)
Title of host publicationMicroRNA in Development and in the Progression of Cancer
PublisherSpringer New York
Pages139-157
Number of pages19
ISBN (Electronic)9781489980656
ISBN (Print)1489980644, 9781489980649
DOIs
Publication statusPublished - Jan 1 2014
Externally publishedYes

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Keywords

  • Acute myeloid leukemia (AML)
  • Hematopoietic stem cells
  • Leukemia
  • Leukemia stem cells
  • MicroRNAs
  • Self-renewal

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Yalcin, S., Chung, S. S., & Park, C. Y. (2014). The role of MicroRNAs in hematopoietic stem cells and leukemia development. In MicroRNA in Development and in the Progression of Cancer (pp. 139-157). Springer New York. https://doi.org/10.1007/978-1-4899-8065-6_8