The role of microRNAs in prostate cancer progression

U. Ging Lo, Diane Yang, Jer Tsong Hsieh

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Prostate cancer (PCa) is the most common male malignancy and the second highest cause of cancer-related mortality in United States. MicroRNAs (miRNAs) are small non-coding RNAs that represent a new mechanism to regulate mRNA post-transcriptionally. It is involved in diverse physiological and pathophysiological process. Dysregulation of miRNAs has been associated with the multistep progression of PCa from prostatic intraepithelial neoplasia (PIN), localized adenocarcinoma to metastatic castration-resistance PCa (CRPC). Identification of unique miRNA could provide new biomarkers for PCa and develop into therapeutic strategies. In this review, we will summarize a broad spectrum of both tumor suppressive and oncogenic miRNAs, and their mechanisms contribute to prostate carcinogenesis.

Original languageEnglish (US)
Pages (from-to)228-241
Number of pages14
JournalTranslational Andrology and Urology
Volume2
Issue number3
DOIs
StatePublished - Sep 2013

Keywords

  • Androgen receptor (AR)
  • Castration-resistant prostate cancer (CRPC)
  • Epithelial-to-mesenchymal transition (EMT)
  • MicroRNA (miRNA)

ASJC Scopus subject areas

  • Reproductive Medicine
  • Urology

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