Abstract
Prostate cancer (PCa) is the most common male malignancy and the second highest cause of cancer-related mortality in United States. MicroRNAs (miRNAs) are small non-coding RNAs that represent a new mechanism to regulate mRNA post-transcriptionally. It is involved in diverse physiological and pathophysiological process. Dysregulation of miRNAs has been associated with the multistep progression of PCa from prostatic intraepithelial neoplasia (PIN), localized adenocarcinoma to metastatic castration-resistance PCa (CRPC). Identification of unique miRNA could provide new biomarkers for PCa and develop into therapeutic strategies. In this review, we will summarize a broad spectrum of both tumor suppressive and oncogenic miRNAs, and their mechanisms contribute to prostate carcinogenesis.
Original language | English (US) |
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Pages (from-to) | 228-241 |
Number of pages | 14 |
Journal | Translational Andrology and Urology |
Volume | 2 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2013 |
Keywords
- Androgen receptor (AR)
- Castration-resistant prostate cancer (CRPC)
- Epithelial-to-mesenchymal transition (EMT)
- MicroRNA (miRNA)
ASJC Scopus subject areas
- Reproductive Medicine
- Urology