Abstract
The nuclear factor kB (NF-kB) transcription factor family plays a critical role in regulating the immune system. Aberrant NF-kB signalling is frequently associated with inflammation and autoimmune diseases but the mechanisms are unclear. Two NF-kB signalling pathways have been identified: the canonical pathway and the alternative pathway. However, these two signalling pathways do not exist in isolation and cross-regulation commonly occurs. Both pathways play important roles in establishing central tolerance. The alternative pathway appears to be the key signalling component in stromal cells, while the canonical pathway exerts its function more in autonomous T cells. Increased signalling of the canonical pathway is often associated with increased T cell activation, and inflammation and recent studies show that lack of signalling of the alternative pathway could also lead to increased inflammation by impairing central tolerance.
| Original language | English (US) |
|---|---|
| Title of host publication | The Epigenetics of Autoimmune Diseases |
| Publisher | John Wiley and Sons |
| Pages | 39-54 |
| Number of pages | 16 |
| ISBN (Print) | 9780470758618 |
| DOIs | |
| State | Published - Apr 29 2009 |
Keywords
- NF-κB pathway, influencing Treg development
- Nuclear factor κB (NF-κB)
- Receptor activator of NF-κB ligand (RANKL)
- Rel homology domain (RHD)
- Role of NF-κB in central tolerance
- Tumour necrosis factor α (TNF-α) and interleukin (IL)-1, inducing NF-κB pathway
- Twist and PIAS1, inhibiting RelA transactivation activity
- Ubiquitination in activation of NF-κB pathways
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology