The role of NK cells in the development of autoantibodies

Dorothy Yuan, Suwannee Thet, Xin J. Zhou, Edward K. Wakeland, Tam Dang

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The systemic lupus erythematosus (Sle1) interval from the NZM2410 mouse strain has been shown to be responsible for high levels of autoantibody production against antinuclear antibodies (ANA) when transferred into C57BL/6 mice. B cells derived from the B6.Sle1 strain are required for the production but help from both T-dependent and independent sources have been documented. Using radiation chimeras constructed in a strain of mice that is chronically depleted of Natural killer (NK) cells, but not NKT cells, we have examined the role of NK cells in the development of ANA in this context. Our results show that in the presence of intact T cell help depletion of NK cells does not affect ANA production. However, when T cell help is compromised, the prevalence of animals producing ANA is significantly decreased suggesting that NK cells can provide help for the T-independent production of ANA. Further experiments provide a possible mechanism for the NK-cell dependence.

Original languageEnglish (US)
Pages (from-to)641-651
Number of pages11
JournalAutoimmunity
Volume44
Issue number8
DOIs
StatePublished - Dec 1 2011

Keywords

  • Antinuclear antibodies
  • Bone marrow chimeras
  • Cytokines
  • NK cells
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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